偏执型精神分裂症与4个涉及多巴胺代谢的基因之间的关联分析

遗传 ›› 2006, Vol. 28 ›› Issue (4): 403-406.

偏执型精神分裂症与4个涉及多巴胺代谢的基因之间的关联分析

李俊宁¹;许琪²;沈岩²;季梁¹

1.清华大学生物信息学教育部重点实验室清华大学自动化系，北京 100084;

2.中国医学科学院基础医学研究所中国协和医科大学基础医学院医学分子生物学国家重点实验室，北京 100005

收稿日期:2005-05-17 修回日期:2005-07-08 出版日期:2006-04-10 发布日期:2006-04-10
通讯作者: 季梁

An Association Study between Paranoid Schizophrenia and Four Genes Involved in Dopamine Metabolism

LI Jun-Ning, XU Qi, SHEN Yan, JI Liang

1.The MOE Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing 100084, China;2.National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China

Received:2005-05-17 Revised:2005-07-08 Online:2006-04-10 Published:2006-04-10
Contact: Liang Ji

摘要/Abstract

摘要：

精神分裂症是由多基因相互作用导致的复杂疾病。对其易感基因，儿茶酚氧位甲基转移酶基因（COMT）的众多报道充满了矛盾。在对偏执型精神分裂症研究中，我们用多基因座关联分析法研究了4个涉及神经递质多巴胺代谢的基因之间的相互作用。分析结果支持如下假说：COMT-136-BclI对Val^108/158Met有调控作用。当前者的基因型是CC时，后者的易感等位基因型是Met（A）；而当前者的基因型是GG时，后者的易感等位基因型是Val（G）。这一新的假说可以解释此前单基因座分析对Val^108/158Met(COMT)的截然相反的报道，同时也显示了多基因座分析对复杂疾病研究的必要性。

关键词: 偏执型精神分裂症, 儿茶酚氧位甲基转移酶基因, 多基因座关联分析

Abstract: Schizophrenia is a complex disease caused by interactions among multiple genes. Reports of one of its susceptibility genes, ethyltracatechol-O-mnsferase (COMT) have been conflicting. In the present study on paranoid schizophrenia, we have performed a multilocus association study to analyze the interactions among 4 genes that are involved in dopamine metabolism. Result supports the hypothesis that COMT-136-BclI regulates Val^108/158Met. When the genotype of the former is CC, Met (A) is the genotype of susceptibility allele Val^108/158Met; and when the genotype of the former is GG, Val (G) is the genotype of susceptibility allele Val^108/158Met. This new hypothesis may explain the conflicting results about Val^108/158Met (COMT) obtained by single-locus analyses. It also illustrates that multilocus analysis is necessary for the research of complex diseases.

李俊宁，许琪，沈岩，季梁. 偏执型精神分裂症与4个涉及多巴胺代谢的基因之间的关联分析[J]. 遗传, 2006, 28(4): 403-406.

LI Jun-Ning, XU Qi, SHEN Yan, JI Liang. An Association Study between Paranoid Schizophrenia and Four Genes Involved in Dopamine Metabolism[J]. HEREDITAS, 2006, 28(4): 403-406.