遗传 ›› 2006, Vol. 28 ›› Issue (8): 1023-1030.

• 专论与综述 • 上一篇    下一篇

动物体节发生模型及其相关基因研究进展

刘 静1,2, 王 娜1,2, 朱作言1   

  1. 1. 淡水生态及生物技术国家重点实验室,中国科学院水生生物研究所,武汉 430072;2. 中国科学院研究生院, 北京 100039

  • 收稿日期:2005-12-12 修回日期:2006-02-24 出版日期:2006-08-10 发布日期:2006-08-10
  • 通讯作者: 朱作言

Somitogenesis Models and Related Genes in Animals

LIU Jing 1,2, WANG Na 1,2, ZHU Zuo-Yan 1

  

  1. 1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

  • Received:2005-12-12 Revised:2006-02-24 Online:2006-08-10 Published:2006-08-10
  • Contact: ZHU Zuo-Yan

摘要: 脊椎动物在胚胎发育的过程中沿身体前后轴形成一定数目的暂时性结构—体节(somite),随着胚胎的继续发育每个体节分化成为生骨节,生皮节和生肌节,继而生成各种组织。近三十年来,研究者们就体节的发生和发育提出了多种解释模型,这包括时钟波阵面模型,反应扩散模型,时钟诱导模型,时钟痕迹模型等,虽然这些模型能从不同角度不同程度来解释动物体节发生和发育的不同现象, 但无一能够解释体节发生和发育的全部。然而,大多数模型都提出了时钟分割(segmental clock)这一概念。鸡胚中的c-hairy1和c-hairy2,鸡胚、小鼠中的lunatic fringe以及斑马鱼中的her1, Delta C等几种基因的表达图式的研究为模型中分割时钟的存在提供了分子生物学上的有力证据。

关键词: 时钟分割, 体节发育, l-fng, 循环基因, c-hairy1

Abstract: Many animals form a number of temporary structures along their anterior-posterior axis during embryonic development – somites. Cells in somites differentiate to form the sclerotome (forms vertebral column), the dermotome (forms dermis) and myotome (forms muscle). During the last three decades, several models have been proposed to explain the formation of somites, including the clock and wavefront model, the reaction-diffusion type model, clock and induction model, clock and trail model etc. Although some of them are satisfactory in the different aspects of somitogenesis, no one can explain the formation and regulation of somites perfectly. But, most models proposed the segmental clock. Expression patterns of c-hairy1, c-hairy2 in chicken, l-fng in chicken and mouse, her1 and Delta C in zebrafish present powerful evidence for the existence of segmental clock.

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