遗传 ›› 1999, Vol. 21 ›› Issue (4): 15-18.
徐振波;吴梅筠;孙光云;李荣华;张林;赖跃 XU Zhen-bo;WU Mei-jun;SUN Guang-yun;LI Rong-hua;ZHANG Lin;LAI Yue
摘要： 用扩增片断长度多态性技术分析短串联重复序列（STR）DHFRP2位点的DNA多态性, 在156个中国成都地区汉族无关个体中发现6个等位基因，19种基因型，并首次发现一重复单元数不是4的整数倍的等位基因，该等位基因按孟德尔遗传规律遗传。观察的基因型分布符合Hardy-Weinberg定律，其个人鉴别力（DP）为0.87，杂合度为67.3%，多态性信息量（PIC）为0.68，非父排除率（CE）为45.5%，家系分析结果表明, 该位点符合孟德尔遗传法则。
Abstract： Analyzes polymorphism of short tandem repeat locus (DHFRP2) by using Amp-FLP. Six alleles and nineteen genotypes were observed in 156 unrelated individuals of Chinese Hans in Chengdu. Meanwhile, we first discovered a new allele, its repeat monomers is not integral times of four, which is in conformity with Mendelian inheritance. The allelic discriminating power (DP), observed heterozygocity (h), polymorphism information content (PIC) and chances of paternity exclusion (CE) are 0.87, 67.3%, 0.68 and 45.5% respectively. The distribution of its genotypes tally with Hardy-Weinberg equilibrium and family study manifested that the locus is in conformity with medelian inheritance.
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