遗传 ›› 2013, Vol. 35 ›› Issue (10): 1153-1166.doi: 10.3724/SP.J.1005.2013.01153

• 综述 • 上一篇    下一篇

MicroRNA对胚胎干细胞的多能性网络调控

白银山, 李莉, 卫恒习, 朱翠, 张守全   

  1. 华南农业大学动物科学学院, 动物基因组与分子育种广东省重点实验室, 广州510642
  • 收稿日期:2013-04-01 修回日期:2013-05-28 出版日期:2013-10-20 发布日期:2013-10-25
  • 通讯作者: 张守全, 教授, 博士生导师, 研究方向:动物遗传与繁育。 E-mail:sqzhang@scau.edu.cn
  • 作者简介:白银山, 博士研究生, 研究方向:生殖生理与生物技术。Tel: 020-85285897; E-mail: xuefei200403@163.com
  • 基金资助:

    国家重点基础研究发展计划(973计划)项目(编号:2011CB944202; 2010CB945001)和国家科技支撑计划(编号:2011BAD19B03)资助

The effect of microRNAs on the regulatory network of pluripotency in embryonic stem cells

BAI Yin-Shan, LI Li, WEI Heng-Xi, ZHU Cui, ZHANG Shou-Quan   

  1. Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
  • Received:2013-04-01 Revised:2013-05-28 Online:2013-10-20 Published:2013-10-25

摘要:

胚胎干细胞(Embryonic stem cells, ESCs)是一类能够无限增殖和诱导分化为多种类型细胞的干细胞。MicroRNA(miRNA)是一类内源性具有调控基因表达功能的非编码RNA, 在ESCs增殖和分化过程中起重要作用。MiRNA可以通过对ESCs多能性网络中的转录因子、细胞周期、表观遗传学、信号转导等方面调控, 促使ESCs维持多能性状态。文章重点综述了miRNA的生成过程、调控ESCs多能性的主要miRNA家族以及miRNA对ESCs多能性网络调控作用等内容。

关键词: ESCs, miRNA, 多能性, 调控

Abstract:

Embryonic stem cells (ESCs) are pluripotent stem cells characterized by their ability to self-renew and their pluripotency to differentiate into all cell types. MicroRNA (miRNA) is a small non-coding RNA molecule which can regulate transcriptional and post-transcriptional gene expression, and may also play significant roles in regulating proliferation and differentiation of ESCs. The maintenance of pluripotency in ESCs may involve a regulatory network of many factors and pathways regulated by miRNA, which includes ESCs transcription factors, cell cycle regulation, epigenetic modifications as well as intracelluar signal transduction. This review mainly elaborates the biogenesis of miRNA, the miRNA families regulating the pluripotency of ESCs, and the effect of miRNA on the regulatory network of pluripotency in ESCs.

Key words: ESCs, miRNA, pluripotency, regulation