遗传 ›› 2015, Vol. 37 ›› Issue (2): 111-120.doi: 10.16288/j.yczz.14-283

• 综述 •    下一篇

SIRT3与细胞代谢及心血管疾病的相关性

曹丽娟,刘昕訸,查晴,宋倩,杨克,刘艳   

  1. 上海交通大学医学院附属瑞金医院心血管内科,上海 200025
  • 收稿日期:2014-08-26 出版日期:2015-02-20 发布日期:2015-01-19
  • 通讯作者: 刘艳,博士,主任医师,硕士生导师,研究方向:动脉粥样硬化。E-mail:liuyan_ivy@126.com
  • 作者简介:曹丽娟,硕士研究生,专业方向:动脉粥样硬化。Tel:021-64370045;E-mail:caolijuanqq@163.com
  • 基金资助:
    国家自然科学基金项目(编号:81200204,81470547)资助

The relationship of SIRT3 with cellular metabolism and cardiovascular diseases

Lijuan Cao,Xinhe Liu,Qing Zha,Qian Song,Ke Yang,Yan Liu   

  1. Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2014-08-26 Online:2015-02-20 Published:2015-01-19

摘要: 蛋白去乙酰化酶在细胞生理过程中发挥着极为重要的作用。人蛋白去乙酰化酶包括HDACⅠ、HDACⅡ、HDACⅢ和HDACⅣ4个家族。其中第Ⅲ类即Sir2(Silent information regulator 2)家族包括7个成员——SIRT1~ SIRT7,每个成员都具有不同的细胞定位,并且发挥不同的生物学功能。作为主要定位于线粒体的组蛋白去乙酰化酶,SIRT3不仅调节细胞的能量代谢,并在细胞凋亡、肿瘤生长和一些疾病中发挥作用。文章综述了SIRT3在细胞代谢中的生物学功能以及其在心血管疾病中的研究进展。

关键词: SIRT3, 组蛋白去乙酰化酶, 细胞代谢, 心血管疾病

Abstract: Protein deacetylases play an extremely crucial role in cellular biological processes and have been categorized into four families (HDACⅠ, HDACⅡ, HDACⅢ and HDACⅣ) in human. Of them, HDACⅢ, also known as the Sir2 (Silent information regulator 2) family, contains seven members, SIRT1-7, each exhibiting different cellular localization and biological function. As a major mitochondrial deacetylase, SIRT3 not only modulates cellular metabolism, but also plays important roles in apoptosis, tumor growth, aging and a number of other diseases. In this review, we summarize recent findings related to SIRT3 with an emphasis on its biological functions in regulating cell metabolism and its possible roles in cardiovascular diseases.

Key words: SIRT3, HDAC, cell metabolism, cardiovascular diseases