m 6A修饰及其对病毒复制过程调控研究进展

doi:10.16288/j.yczz.19-042

遗传 ›› 2019, Vol. 41 ›› Issue (5): 404-412.doi: 10.16288/j.yczz.19-042

m ⁶A修饰及其对病毒复制过程调控研究进展

薛鹏¹,蒋涛¹,沈兴家^1,²()

^1. 江苏科技大学生物技术学院,江苏省蚕桑生物学与生物技术重点实验室,镇江 212018
^2. 中国农业科学院蚕业研究所,农业部蚕桑遗传改良重点实验室,镇江 212018

收稿日期:2019-02-20 修回日期:2019-04-08 出版日期:2019-05-20 发布日期:2019-04-16
作者简介:薛鹏,硕士研究生,专业方向：基因表达调控。E-mail: xuepeng0603@163.com
基金资助:
国家自然科学基金项目(31672490);江苏省自然科学基金项目(BK20151322);江苏省高校自然科学研究重大项目(15KJA180001)

Advances in m ⁶A modification and its regulation of viral replication

Peng Xue¹,Tao Jiang¹,Xingjia Shen^1,²()

^1. Jiangsu Key Laboratory of Sericutural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212018, China
^2. Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212018, China

Received:2019-02-20 Revised:2019-04-08 Published:2019-05-20 Online:2019-04-16
Supported by:
National Natural Science Foundation of China(31672490);Natural Science Foundation of Jiangsu Province(BK20151322);Major Project of Natural Science Foundation for Universities of Jiangsu Province(15KJA180001)

摘要/Abstract

摘要：

N ⁶-甲基腺嘌呤(N ⁶-methyladenosine, m ⁶A)修饰是一种在真核生物中普遍存在的RNA修饰方式,在mRNA转运、稳定、翻译等过程中具有重要作用。m ⁶A修饰在病毒复制周期中扮演不同的角色,病毒的复制和宿主对病毒的免疫反应都受到m ⁶A甲基化的影响。本文总结了近年来关于m ⁶A修饰方面的分子作用机制及其对病毒复制以及宿主免疫反应的影响相关研究,以期为病毒生命周期中的表观遗传调控研究提供一定的参考。

关键词: N ⁶-甲基腺嘌呤, RNA修饰, 病毒, 复制, 免疫

Abstract:

N ⁶-methyladenosine (m ⁶A) is a prevalent modification of RNA in eukaryotes and plays an important role in the process of mRNA translocation, stabilization and translation. m ⁶A exerts different influences on the viral replication cycle, and both viral replication and host immune response to the virus are affected by m ⁶A. In this review, we summarize recent studies on the mechanism of m ⁶A modification and its effects on viral replication and host immune response, in order to provide a reference for epigenetic regulation in the viral life cycle.

Key words: N ⁶-methyladenosine, RNA modification, virus, replication, immunity

薛鹏, 蒋涛, 沈兴家. m ⁶A修饰及其对病毒复制过程调控研究进展[J]. 遗传, 2019, 41(5): 404-412.

Peng Xue, Tao Jiang, Xingjia Shen. Advances in m ⁶A modification and its regulation of viral replication[J]. Hereditas(Beijing), 2019, 41(5): 404-412.

参考文献

[1]	Desrosiers R, Friderici K, Rottman F . Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci USA, 1974,71(10):3971-3975.
[2]	Perry RP, Kelley DE . Existence of methylated messenger RNA in mouse L cells. Cell, 1974,1(1):37-42.
[3]	Ye F, Dan D, Gideon R, Chuan H . Gene expression regulation mediated through reversible m 6A RNA methylation . Nat Rev Genet, 2014,15(5):293-306.
[4]	LI YL, YU J, Song SH . Recent progresses in RNA N 6-methyladenosine research . Hereditas (Beijing), 2013,35(12):1340-1351.
[4]	李语丽, 于军, 宋述慧 . RNA 中6-甲基腺嘌呤的研究进展. 遗传, 2013,35(12):1340-1351.
[5]	Zhao BS, Roundtree IA, He C . Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol, 2016,18(1):31-42.
[6]	Roignant JY, Soller M . M6A in mRNA: an ancient mechanism for Fine-Tuning gene expression. Trends in Genetics, 2017,33(6):380-390.
[7]	Wu R, Jiang D, Wang Y, Wang X . N 6 -methyladenosine (m 6A) methylation in mRNA with a dynamic and reversible epigenetic modification . Mol Biotechnol, 2016,58(7):450-459.
[8]	Krug RM, Morgan MA, Shatkin AJ . Influenza viral mRNA contains internal N 6-methyladenosine and 5'-terminal 7-methylguanosine in cap structures . J Virol, 1976,20(1):45-53.
[9]	Moss B, Koczot F . Sequence of methylated nucleotides at the 5'-terminus of adenovirus-specific RNA. J Virol, 1976,17(2):385-392.
[10]	Tan B, Gao SJ . RNA epitranscriptomics: regulation of infection of RNA and DNA viruses by N 6-methyladenosine (m 6A) . Quaest Math, 2018,29(1):125-131.
[11]	Zhang X, Jia GF . RNA epigenetic modification: N 6-methyladenosine . Hereditas(Beijing), 2016,38(4):275-288.
[11]	张笑, 贾桂芳 . RNA表观遗传修饰: N 6-甲基腺嘌呤 . 遗传, 2016,38(4):275-288.
[12]	Schwartz S, Mumbach MR, Jovanovic M, Wang T, Maciag K, Bushkin GG, Mertins P, Ter-ovanesyan D, Habib N, Cacchiarelli D, Sanjana NE, Freinkman E, Pacold ME, Satija R, Mikkelsen TS, Hacohen N, Zhang F, Carr SA, Lander ES, Regev A . Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep, 2014,8(1):284-296.
[13]	Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T . Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. J Biol Chem 2013,288(46):33292-33302.
[14]	Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK . The U 6 snRNA m 6A methyltransferase METTL16 regu

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

m ⁶A修饰及其对病毒复制过程调控研究进展

Advances in m ⁶A modification and its regulation of viral replication

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics