血液发生相关microRNAs研究进展

doi:10.16288/j.yczz.22-198

遗传 ›› 2022, Vol. 44 ›› Issue (9): 756-771.doi: 10.16288/j.yczz.22-198

血液发生相关microRNAs研究进展

孙凤宇¹(), 许强华^1,^2,^3,⁴()

1. 上海海洋大学海洋科学学院,上海 201306
2. 大洋渔业资源可持续开发省部共建教育部重点实验室,上海 201306
3. 国家远洋渔业工程技术研究中心,上海 201306
4. 远洋渔业协同创新中心,上海 201306

收稿日期:2022-06-15 修回日期:2022-08-03 出版日期:2022-09-20 发布日期:2022-08-26
通讯作者: 许强华 E-mail:823050631@qq.com;qhxu@shou.edu.cn
作者简介:孙凤宇,在读硕士研究生,专业方向：海洋生物学、分子生物学。E-mail: 823050631@qq.com。
基金资助:
国家重点研发计划项目(编号)(2018YFD0900601);国家重点研发计划项目(编号)(2018YFC0310600);国家自然科学基金面上项目(编号)(31772826);上海市教委重点科技创新项目(编号)资助(2017-01-07-00-10-E00060)

Research progress of microRNAs involved in hematopoiesis

Fengyu Sun¹(), Qianghua Xu^1,^2,^3,⁴()

1. College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China
2. Key Laboratory of Sustainable Exploitation of Ocean Fisheries Resources, Ministry of Education, Shanghai 201306, China
3. National Distant-water Fisheries Engineering Research Center, Shanghai 201306, China
4. Collaborative Innovation Center for Distant-water Fisheries, Shanghai 201306, China

Received:2022-06-15 Revised:2022-08-03 Online:2022-09-20 Published:2022-08-26
Contact: Xu Qianghua E-mail:823050631@qq.com;qhxu@shou.edu.cn
Supported by:
Supported by the National Key Research and Development Program of China Nos(2018YFD0900601);Supported by the National Key Research and Development Program of China Nos(2018YFC0310600);the National Natural Science Foundation of China No(31772826);the Major Science Innovation Grant from the Shanghai Education Committee No(2017-01-07-00-10-E00060)

摘要/Abstract

摘要：

血液发生对生命体有着十分重要的意义。脊椎动物的血液发生主要表现为造血干细胞的自我更新和分化、造血祖细胞的增殖分化以及血细胞的成熟。血液发生过程的调控涉及多种转录因子、膜受体、造血生长因子和microRNAs等,它们之间相互作用形成多种信号通路及信号通路网。microRNAs是一类非编码RNA,广泛分布于真核生物细胞中,在机体的造血过程中发挥着重要作用。microRNAs的表达受造血相关信号通路中转录因子的调控,而microRNAs的表达能抑制或降低参与造血相关信号通路的转录因子以及更多造血相关调控因子的表达,从而影响血细胞发生相关的信号通路,进而调控造血过程。本文主要介绍了脊椎动物造血过程和血细胞发生相关信号通路,并围绕microRNAs与造血相关转录因子及信号通路之间的作用关系,总结了microRNAs调控血液发生的相关研究进展。

关键词: 血细胞发生, 转录因子, 信号通路, microRNAs

Abstract:

Hematopoiesis plays an important role(s) in maintenance and physiology of life. Hematopoiesis in vertebrates mainly includes self-renewal of the hematopoietic stem cells, proliferation and differentiation of the hematopoietic progenitor cells, and maturation of the blood cells. The regulation of hematogenesis involves a variety of transcription factors, membrane receptors, hematopoietic growth factors, and microRNAs, which interact with each other and form a variety of signaling pathways and signal networks. MicroRNAs are a class of non-coding RNAs widely distributed in eukaryotic cells and play important roles in the hematopoietic process. The expression of microRNAs is regulated by transcription factors involved in hematopoietic signaling pathways. In turn, their expression can inhibit or down-regulate those of transcription factors involved in hematopoietic related signaling pathways and other related regulatory factors, thereby affecting the signaling pathways related to hematopoiesis and ultimately the hematopoietic process. In this review, we introduce the hematopoiesis processes and related signal pathways in vertebrates, focusing on the relationships between microRNAs and hematopoietic transcription factors and signal pathways, and summarizing the recent research progress of microRNAs in hematopoiesis.

Key words: hematopoiesis, transcription factor, signal pathway, microRNAs

孙凤宇, 许强华. 血液发生相关microRNAs研究进展[J]. 遗传, 2022, 44(9): 756-771.

Fengyu Sun, Qianghua Xu. Research progress of microRNAs involved in hematopoiesis[J]. Hereditas(Beijing), 2022, 44(9): 756-771.

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调控方式/祖细胞	miRNA	靶基因或参与通路	参考文献
促进自我更新和抑制分化	miR-199	Klf12、Tox3、Cdk18	[14]
	miR-127-3p		[15]
	miR-125a	c-kit等	[16]
	miR-22	Tet2	[17]
	miR-143、miR-145	TGF-β通路	[18]
	miR-29a	Dnmt3a	[19]
维持静止状态	miR-126	PI3K/Akt/GSK3β通路	[20]
维持静止状态	miR-21	Pdcd4;NF-κB通路	[21]
在机体应激、老化和接受辐射状态下抑制凋亡、促进再生	miR-132	Foxo3	[22]
	miR-146a	Traf6	[23]
	miR-21		[24]
	miR-34a		[25]
髓系祖细胞(CMP)	mirn23a	PI3K/Akt通路、BMP/Smad通路	[27]
髓系祖细胞(CMP)	miR-125b	Lin28A	[28]
巨核/红系祖细胞(MEP)	miR-125b-2	Dicer1、St18	[29]
淋巴祖细胞(CLP)	miR-125b	Bmf、Klf13	[30]

调控方式	miRNA	靶基因或参与通路	参考文献
促进红细胞分化	miR-144/451 miR-142		[7]
	miR-27a、miR-24	GATA-1/2 switch—miR-27a/24—GATA-2环	[31]
	miR-23a	Shp2	[35]
	miR-15a	c-myb	[37]
	miR-17-92	Tal1	[38]
	miR-486-5p	Foxo1、Pten;Akt通路	[36]
控制血红蛋白合成与积累、染色质凝结和去核及红细胞结构维持	miR-462-731		[34]
	let-7	Lin28b—let-7—Hmga2轴	[39]
	miR-451		[41]
	miR-142	Cfl2、Grlf1、Wasl	[42]
在极端环境下促进红细胞生成	miR-210-3p	可能是Smad2	[43]
在极端环境下促进红细胞生成	miR-486-5p	Magi1、Rassf5;Rap1通路	[44]
MEP发育至成熟巨核细胞	miR-22	Gfi1	[45]
	miR-126、miR-150	c-myb	[46]
	miR-1273g-3p miR-619-5p	Cdk10、Cdk11、CyclinF	[47]
	miR-1915-3p	Rhob;Rho/ROCK通路	[48]
	miR-146b	Nolc1	[49]

调控过程	miRNA	靶基因或参与通路	参考文献
树突状细胞的形成	miR-564	Tp53	[56]
	miR-22	Irf8	[57]
	miR155	c-fos	[58]
单核/巨噬细胞的形成	miR-146a		[59]
	miR-22	Evi1	[60]
	miR-21		[61]
	miR-200-3p	p38IP	[62]
粒细胞生成	miR-223	Mef2c、Igf1r;与C/EBPα、NFI-A形成回路	[63~65]
	miR-708	Sdc1	[66]
	miR-143	Erk5	[67]
	miR-21		[68]

调控过程	miRNA	靶基因或参与通路	参考文献
NK细胞的发育和成熟	miR-150 miR-15/16	c-myb	[69,71]
同时作用于B和T两种淋巴细胞的增殖、发育和稳态	miR-181	Pten;PI3K通路	[74]
	miR-150	c-myb;Notch通路	[75,76]
	miR-142-3p	Baff-r、Cdkn1b	[77,78]
祖B细胞产生成熟B细胞	miR-17~92	Bim	[79]
	miR-29	Pten;PI3K通路	[81]
	miR-191	Tcf3、Egr1、Foxp1	[82]
	miR-29c	Rag1	[83]
祖T细胞产生成熟T细胞	miR-191	Irs1	[85]
	miR-150	c-myb、Pdap1	[86]
	miR-33a/b miR-181a	S1pr1	[87]
	miR-181a	TCRa、CD69、Bcl2;Notch通路、 pre-TCR信号通路	[88,89]

血液发生相关microRNAs研究进展

Research progress of microRNAs involved in hematopoiesis

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