摘要： MEF2属于MADS (MCM1,agamous,deficiens,serum response factor)框转录因子家族，在肌肉发生过程中起着重要的调节作用。本文综述了肌肉发生过程中MEF2基因的表达调控、MEF2蛋白活性调节及其激活靶基因表达等，着重阐述了MEF2在钙调素-钙调磷酸酶与TGF-β-Smad通路中的作用，并分析了MEF2成为肌肉发生中承接信号分子与结构蛋白之间桥梁的原因。

MEF2 and Myogenesis
CHENG Zhen-long1,ZHU Da-hai1,ZHANG Zhi-qian2
1.Molecular and Cellular Developmental Biology Laboratory,Harbin Institute of Technology,Harbin 150001,China;
2.Department of Cell Biology,Beijing Institute for Cancer Research,Medical School,Beijing University,
Beijing 100034,China
Abstract:Recent genetic and biochemical studies have demonstrated that skeletal muscle growth and differentiation in vertebrates are controlled by a core regulatory network which consists of two families of transcriptional factors,the MyoD group basic helix-loop-helix (bHLH) muscle regulatory factors (MRFs) and the myocyte enhancer factor 2 (MEF2) group of MADS-box regulators.During development,MEF2 interacts genetically and physically with different members of this myogenic network and together they cooperate to positively or negatively regulate transcription of downstream muscle-specific differentiation genes.This paper reviews current understanding of molecular mechanism of these interactions and essential roles that MEF2 plays in skeletal muscle growth and differentiation during development.
Key words：MEF2；myogenesis；signal transduction

关键词: 肌肉发生, MEF2, 信号传导