竞争性内源RNA的生物学功能及其调控

doi:10.16288/j.yczz.15-073

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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (8): 756-764.doi: 10.16288/j.yczz.15-073

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The biological functions and regulations of competing endogenous RNA

Jingqiu Li^{1, 2}, Jie Yang^{1, 2}, Ping Zhou^{1, 2}, Yanping Le^{1, 2}, Zhaohui Gong^{1, 2}

1. Institute of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, China;
2. Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China

Received:2015-02-09 Revised:2015-04-07 Online:2015-08-20 Published:2015-08-20

Abstract

Abstract: Recent studies demonstrate that RNA species could regulate each other by competing for shared microRNA response elements (MREs). This regulatory model is called competing endogenous RNA (ceRNA). Currently, the identified ceRNAs cover coding and non-coding RNAs. The latter includes pseudogene transcripts, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and so on. In this review, we summarize the biological functions of regulatory networks consisting of various types of ceRNAs and their roles in the pathological and physiological processes. Additionally, several factors that may regulate ceRNAs were discussed.

Key words: competing endogenous RNA, microRNA response element, pseudogene, long non-coding RNA, circular RNA

Jingqiu Li, Jie Yang, Ping Zhou, Yanping Le, Zhaohui Gong. The biological functions and regulations of competing endogenous RNA[J]. HEREDITAS(Beijing), 2015, 37(8): 756-764.

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The biological functions and regulations of competing endogenous RNA

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