MicroRNA调控动物脂肪细胞分化研究进展

doi:10.16288/j.yczz.15-233

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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (12): 1175-1184.doi: 10.16288/j.yczz.15-233

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MicroRNA regulates animal adipocyte differentiation

Jinwei Zhang, Yi Luo, Yuhao Wang, Liujun He, Mingzhou Li, Xun Wang

College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University,Chengdu 611130, China

Received:2015-05-20 Online:2015-12-20 Published:2015-09-16

Abstract

Abstract: Adipose tissues play a critical role in the regulation of energy metabolism and homeostasis, and is also an important endocrine organ. Adipocyte differentiation is a complicated physiological process during which mesenchymal stem cells differentiate into adipocytes. This process is synergistically regulated by a large number of transcription factors, hormones and signaling pathway molecules. As a class of endogenous non-coding RNA (ncRNA), microRNAs (miRNAs) regulate gene expression mainly through post-transcriptional translational repression. In recent years, numerous studies have demonstrated that miRNA could have an impact on adipocyte differentiation and adipogenesis by modulating the expression levels of several adipogenic transcription factors and key signaling molecules. In this review, we summarize the mechanism of miRNA in regulating the differentiation of white/brown/beige adipocytes and the relevant signaling pathways and key factors, in the hope of providing theoretical guidance and new thoughts for treating obesity and other metabolic diseases.

Key words: miRNA, white adipocyte, brown adipocyte, beige adipocyte, differentiation

Jinwei Zhang, Yi Luo, Yuhao Wang, Liujun He, Mingzhou Li, Xun Wang. MicroRNA regulates animal adipocyte differentiation[J]. HEREDITAS(Beijing), 2015, 37(12): 1175-1184.

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MicroRNA regulates animal adipocyte differentiation

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