Hippo信号通路与肝脏稳态调控及疾病发生

doi:10.16288/j.yczz.17-064

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 607-616.doi: 10.16288/j.yczz.17-064

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Hippo signaling pathway in liver tissue homeostasis

Yuxi Li(),Junhong Li,Dawang Zhou(),

Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, China

Received:2017-02-26 Revised:2017-05-05 Online:2017-07-20 Published:2017-05-31
Supported by:
the National Natural Science Foundation of China(31625010,U1505224,J1310027)

Abstract

Abstract:

Liver cancer and diseases have become the leading cause of deaths in China. Liver diseases including liver failure and liver cancer can be genetic or caused by a variety of factors that damage the liver, such as viruses and alcohol overdose. However, the underlying mechanisms that maintain liver homeostasis remain unclear. Recent studies show that the Hippo signaling pathway plays a critical role in maintaining liver tissue homeostasis. Dysregulation of the Hippo signaling pathway impairs liver regeneration and remarkly enhances liver overgrowth and tumorigenesis. In this review, we summarize recent progresses on the roles and regulation mechanisms of the Hippo signaling pathway in liver development and diseases.

Key words: Hippo/Yap, liver development, liver cancer, liver regeneration

Yuxi Li, Junhong Li, Dawang Zhou, . Hippo signaling pathway in liver tissue homeostasis[J]. Hereditas(Beijing), 2017, 39(7): 607-616.

References

[1]	Zhou DW, Zhang YY, Wu HT, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, Avruch J. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci USA, 2011, 108(49): E1312-E1320.
[2]	Zhou Q, Li L, Zhao B, Guan KL. The hippo pathway in heart development, regeneration, and diseases. Circ Res, 2015, 116(8): 1431-1447.
[3]	Zhou DW, Medoff BD, Chen LF, Li LQ, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of na?ve T cells. Proc Natl Acad Sci USA, 2008, 105(51): 20321-20326.
[4]	Geng J, Sun XF, Wang P, Zhang SH, Wang XZ, Wu HT, Hong LX, Xie CC, Li X, Zhao H, Liu QX, Jiang MT, Chen QH, Zhang JJ, Li Y, Song SY, Wang HR, Zhou RB, Johnson RL, Chien KY, Lin SC, Han JH, Avruch J, Chen LF, Zhou DW. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol, 2015, 16(11): 1142-1152.
[5]	Yu FX, Guan KL. The Hippo pathway: regulators and regulations. Genes Dev, 2013, 27(4): 355-371.
[6]	Huang JB, Wu SA, Barrera J, Matthews K, Pan DJ. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell, 2005, 122(3): 421-434.
[7]	Wu SA, Huang JB, Dong JC, Pan DJ. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell, 2003, 114(4): 445-456.
[8]	Chan EHY, Nousiainen M, Chalamalasetty RB, Sch?fer A, Nigg EA, Silljé HHW. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene, 2005, 24(12): 2076-2086.
[9]	Yin F, Yu JZ, Zheng YG, Chen Q, Zhang NL, Pan DJ. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell, 2013, 154(6): 1342-1355.
[10]	Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G. The tumour- suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol, 2006, 8(1): 27-36.
[11]	Bennett FC, Harvey KF. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol, 2006, 16(21): 2101-2110.
[12]	Greenbaum LE. The ductal plate: a source of progenitors and hepatocytes in the adult liver. Gastroenterology, 2011, 141(4): 1152-1155.
[13]	Zhang NL, Bai HB, David KK, Dong JX, Zheng YG, Cai J, Giovannini M, Liu PT, Anders RA, Pan DJ. The Merlin/NF2 tumor suppressor functions th

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