缺氧诱导因子(HIFs)在肾癌发生中的作用及其分子机制

doi:10.16288/j.yczz.17-406

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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (5): 341-356.doi: 10.16288/j.yczz.17-406

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Roles and molecular mechanisms of hypoxia-inducible factors in renal cell carcinoma

Junxia Zou¹,Ke Chen²()

^1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
^2. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Received:2017-12-11 Revised:2018-01-13 Online:2018-05-20 Published:2018-03-30
Contact: Chen Ke E-mail:kechen@hust.edu.cn
Supported by:
Supported by National Natural Science Foundation of China(81402105);Supported by National Natural Science Foundation of China(81772721)

Abstract

Abstract:

Renal cancer is a common urologic malignancy. However, the therapeutic options for metastatic renal cancer patients are limited. Hypoxia (low oxygen) is a fundamental microenvironmental determinant of solid tumor pathophysiology. Recent data from molecular and clinical studies indicate that hypoxia-inducible factors (HIFs) play critical roles in the development and progress of renal cell carcinoma (RCC). The HIF transcription factor family is a type of heterodimeric transcription factor consisting of HIF-α and HIF-β subunits and can transcriptionally activate genes that mediate the hypoxic response. In RCC, HIF-1α and HIF-2α have opposing effects: HIF-1α is a tumor suppressor while HIF-2α acts as an oncogene. In this review, we summarize the current advances in understanding the roles and molecular mechanisms of HIF signaling in RCC. We also discuss recent HIF-targeted strategies proposed to improve RCC treatment, which may provide a foundation for further research, including the development of precision medicine for the treatment of RCC.

Key words: hypoxia, hypoxia-inducible transcription factors (HIFs), renal cell carcinoma, von Hippel-Lindau (VHL)

Junxia Zou, Ke Chen. Roles and molecular mechanisms of hypoxia-inducible factors in renal cell carcinoma[J]. Hereditas(Beijing), 2018, 40(5): 341-356.

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Roles and molecular mechanisms of hypoxia-inducible factors in renal cell carcinoma

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