转录因子GATA6在心血管疾病中的作用及其调控机制

doi:10.16288/j.yczz.19-044

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (5): 375-383.doi: 10.16288/j.yczz.19-044

• Review • Previous Articles Next Articles

The roles and regulation mechanism of transcription factor GATA6 in cardiovascular diseases

Zhaoqing Sun¹,Bo Yan^2,^3,⁴()

^1. Cheeloo College of Medicine, Shandong University, Jinan 250012, China
^2. Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining 272029, China
^3. The Center for Molecular Genetics of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining 272029, China
^4. Shandong Provincial Sino-US Cooperation Research Center for Translational Medicine, Affiliated Hospital of Jining Medical University, Jining 272029, China

Received:2019-02-21 Revised:2019-03-18 Online:2019-05-20 Published:2019-05-06
Contact: Yan Bo E-mail:yanbo@mail.jnmc.edu.cn
Supported by:
National Natural Science Foundation of China(81370271);National Natural Science Foundation of China(81400291);National Natural Science Foundation of China(81670341);National Natural Science Foundation of China(81870279)

Abstract

Abstract:

The GATA transcription factor family consists of six members, GATA1 through GATA6, which play important roles in the regulation of cell growth and differentiation, cell survival, and maintenance of body functions. Current studies regarding GATA6 transcription factor confirm that GATA6 plays a crucial role in the differentiation, development, and function of the human heart. Genetic mutations of GATA6 are associated with a variety of congenital heart diseases, dysfunction of the cardiac conduction system causing various arrhythmias, coronary artery disease, and dilated and hypertrophic cardiomyopathies. The relationship between GATA6 and the human heart is also impacted by multiple other genes and interactions in the body. In this review, we summarize the research and current knowledge of the GATA6 transcription factor related to the human heart and multiple pathologies which provides understanding of its genetic basis to enable future personalized gene therapy and to promote the development and incorporation of basic research into clinical medicine.

Key words: transcription factor GATA6, cardiovascular disease, gene mutation, molecular genetics

Zhaoqing Sun, Bo Yan. The roles and regulation mechanism of transcription factor GATA6 in cardiovascular diseases[J]. Hereditas(Beijing), 2019, 41(5): 375-383.

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