转录中介体复合物在心血管发育和疾病中的转录调控作用

doi:10.16288/j.yczz.21-411

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Hereditas(Beijing) ›› 2022, Vol. 44 ›› Issue (5): 383-397.doi: 10.16288/j.yczz.21-411

• Review • Previous Articles Next Articles

Transcriptional regulation of transcriptional Mediator complexes in cardiovascular development and disease

Yuan Zhang¹(), Yuting Zhao¹, Lenan Zhuang^1,^2,³(), Jin He³()

1. Department of Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou 310058, China
2. Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Key Laboratory of Cardiovascular Intervention and Regeneration Medicine of Zhejiang Province, Hangzhou 310016, China
3. Institute of Animal Genetics, Breeding and Reproduction, College of Animal Science, Zhejiang University, Hangzhou 310058, China

Received:2022-01-18 Revised:2022-03-03 Online:2022-05-20 Published:2022-03-28
Contact: Zhuang Lenan,He Jin E-mail:zhangyuan2020@zju.edu.cn;hejin@zju.edu.cn
Supported by:
Supported by the National Key Research and Development Program Nos(2019YFE0117400);Supported by the National Key Research and Development Program Nos(2021YFA0805902);the National Natural Science Foundation of China(81941003);the Fundamental Research Funds for the Central Universities No(2020XZZX002-20)

Abstract

Abstract:

During the development of the mammalian cardiovascular system, the formation of a mature and fully functional cardiovascular system needs the fine coordination of the morphogenesis of various molecules, cells, tissues, and organs. Abnormalities in these processes usually lead to serious congenital heart defects. The determination and maintenance of cell fate in multicellular organisms depend to a large extent on the precise timing and control of RNA polymerase II (Pol II) transcription, and the transcription Mediator complex plays an irreplaceable role in the Pol II transcription process. Mediator is an evolutionarily conserved multi-subunit protein complex, including four parts: head, middle, tail, and kinase. It is a functional bridge between transcription factors and basic transcription machines. In recent years, due to the key role of Mediator in the transcriptional regulation of gene expression, many of human heart diseases have been confirmed to be related to specific Mediator gene mutations, such as heart valve defects, translocation of the great arteries, DiGeorge syndrome and some cardiovascular diseases related to energy homeostasis. In this review, we summarize the role of Mediator in cardiovascular development and disease, focusing on the role of Mediator in the development of cardiovascular disease, and provides a broad idea for the research on Mediator-related cardiovascular system development and diseases.

Key words: Mediator complex, transcriptional regulation, cardiovascular development, cardiovascular disease

Yuan Zhang, Yuting Zhao, Lenan Zhuang, Jin He. Transcriptional regulation of transcriptional Mediator complexes in cardiovascular development and disease[J]. Hereditas(Beijing), 2022, 44(5): 383-397.

Figures/Tables 2

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亚基	心血管疾病	生物进程	研究对象	参考文献
MED1	薄心肌壁综合征	心肌壁、心肌小梁发育异常	人类	[59]
MED12	先天性心脏畸形	心血管系统发育缺陷	人类	[60]
MED13	代谢性心脏病	能量代谢障碍	小鼠	[61]
MED13L	大动脉转位	早期心脏发育缺陷	人类	[62,63]
MED15	DiGeorge综合征	心脏畸形	人类	[64,65]
MED23	心脏水肿、心率降低	血管平滑肌发育异常	斑马鱼	[66]
MED25	心室和(或)心房间隔缺损	MED25与Mediator间相互作用受损	人类	[67]
MED30	扩张性心肌病	心脏线粒体功能障碍	小鼠	[68]
CDK8	过表达导致进行性扩张型心肌病、心力衰竭	左心室心肌细胞显著延长、横管紊乱、钙处理功能障碍	小鼠	[69]

Transcriptional regulation of transcriptional Mediator complexes in cardiovascular development and disease

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