脑发育疾病及发病机制

doi:10.16288/j.yczz.19-133

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (9): 801-815.doi: 10.16288/j.yczz.19-133

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Brain developmental diseases and pathogenic mechanisms

Yisheng Jiang,Zhiheng Xu()

Department of Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

Received:2019-05-13 Revised:2019-07-04 Online:2019-09-20 Published:2019-08-26
Contact: Xu Zhiheng E-mail:zhxu@genetics.ac.cn
Supported by:
Supported by the National Natural Science Foundation of China Nos(31430037);Supported by the National Natural Science Foundation of China Nos(31730108);Strategic Priority Research Program and Innovation Program of the Chinese Academy of Sciences Nos(XDB32020100);Strategic Priority Research Program and Innovation Program of the Chinese Academy of Sciences Nos(QYZDJ-SSW-SMC007);Strategic Priority Research Program and Innovation Program of the Chinese Academy of Sciences Nos(GJHZ1827)

Abstract

Abstract:

Development of the human brain is a strictly complex and precisely regulated process. Brain development includes the proliferation and differentiation of neural progenitor cells, migration and maturation of neurons, myelination of neuronal axons, synaptogenesis and organization of the neural circuits. Abnormalities of these developmental processes can lead to severe malformation and dysfunction of the brain, which may result in brain developmental diseases which have a high medical burden and have attracted global attention. Brain developmental diseases are typically divided into two categories according to abnormal brain morphology and dysfunction: malformation of cortical development (MCD) and neuropsychopathy. Microcephaly and autism spectrum disorder (ASD) are representative disorders of MCD and neuropsychopathy respectively. In this review, we summarize the progresses of these two typical and relevant brain developmental diseases including the mechanism and etiology of their development, gene expression, symptoms, and related to provide theoretical guidance for basic research and management and treatment.

Key words: brain developmental diseases, microcephaly, autism, disease associated genes

Yisheng Jiang,Zhiheng Xu. Brain developmental diseases and pathogenic mechanisms[J]. Hereditas(Beijing), 2019, 41(9): 801-815.

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