衰老导致卵巢功能低下研究进展

doi:10.16288/j.yczz.19-134

[an error occurred while processing this directive]

Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (9): 816-826.doi: 10.16288/j.yczz.19-134

• Review • Previous Articles Next Articles

Advances in the study of ovarian dysfunction with aging

Chuanming Liu¹,Lijun Ding^1,²,Jiayin Li³,Jianwu Dai³(),Haixiang Sun¹()

^1. Reproductive Medicine Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
^2. Center for Clinical Stem Cell Research, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
^3. State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, China

Received:2019-06-28 Revised:2019-07-16 Online:2019-09-20 Published:2019-08-11
Contact: Dai Jianwu,Sun Haixiang E-mail:jwdai@genetics.ac.cn;stevensunz@163.com
Supported by:
Supported by the National Key Research and Development Program of China No.(2018YFC1004700);The Strategic Priority Research Program of the Chinese Academy of Sciences No(XDA01030501)

Abstract

Abstract:

Societal changes regarding the role of women have significant impacts on women’s willingness and the timing of childbearing. Ovarian reserve in woman typically begins to decline at the age of 35, and it is primarily characterized by a reduction in the number of ovarian follicles and a decline in oocyte quality. The clinical diagnosis of ovarian insufficiency relies on multiple variables including changes of follicle stimulating hormone (FSH), serum anti-Müllerian hormone (AMH), inhibin B, antral follicle count, menstruation and age. It is proven that ovarian cells demonstrate dysfunction associated with aging including mitochondrial dysfunction, telomere shortening, impaired DNA repair, epigenetic changes and metabolic/energetic disorders. In this review, we introduce the clinical diagnosis and management of ovarian insufficiency. We mainly discuss the molecular mechanism and potential interventions. We are optimistic that this information and knowledge will inform the important decisions for women and society regarding childbearing.

Key words: ovarian, aging, mitochondrion, heredity, epigenomics

Chuanming Liu,Lijun Ding,Jiayin Li,Jianwu Dai,Haixiang Sun. Advances in the study of ovarian dysfunction with aging[J]. Hereditas(Beijing), 2019, 41(9): 816-826.

References

[1]	Wang T, Gao YY, Chen L, Nie ZW, Cheng W, Liu X, Schatten H, Zhang X, Miao YL . Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig. Aging, 2017,9(6):1552-1564.
[2]	Yuan Y, Hakimi P, Kao C, Kao A, Liu R, Janocha A, Boyd-Tressler A, Hang X, Alhoraibi H, Slater E, Xia K, Cao P, Shue Q, Ching TT, Hsu AL, Erzurum SC, Dubyak GR, Berger NA, Hanson RW, Feng Z . Reciprocal changes in phosphoenolpyruvate carboxykinase and pyruvate kinase with age are a determinant of aging in caenorhabditis elegans. J Biol Chem, 2016,291(3):1307-1319.
[3]	Schandera J, Mackey TK . Mitochondrial replacement techniques: divergence in global policy. Trends Genet, 2016,32(7):385-390.
[4]	Li Q, Geng X, Zheng W, Tang J, Xu B, Shi Q . Current understanding of ovarian aging. Sci China Life Sci, 2012,55(8):659-669.
[5]	Ata B, Seli E . Strategies for controlled ovarian stimulation in the setting of ovarian aging. Semin Reprod Med, 2015,33(6):436-448.
[6]	Tachibana M, Kuno T, Yaegashi N . Mitochondrial replacement therapy and assisted reproductive technology: a paradigm shift toward treatment of genetic diseases in gametes or in early embryos. Reprod Med Biol, 2018,17(4):421-433.
[7]	Kristensen SG, Pors SE, Andersen CY . Improving oocyte quality by transfer of autologous mitochondria from fully grown oocytes. Hum Reprod, 2017,32(4):725-732.
[8]	Hansen KR, Craig LB, Zavy MT, Klein NA, Soules MR . Ovarian primordial and nongrowing follicle counts according to the stages of reproductive aging workshop (STRAW) staging system. Menopause, 2012,19(2):164-171.
[9]	Nelson SM, Telfer EE, Anderson RA . The ageing ovary and uterus: new biological insights. Hum Reprod Update, 2013,19(1):67-83.
[10]	Iliodromiti S, Iglesias Sanchez C, Messow CM, Cruz M, Garcia Velasco J, Nelson SM . Excessive age-related decline in functional ovarian reserve in infertile women: prospective cohort of 15,500 women. J Clin Endocrinol Metab, 2016,101(9):3548-3554.
[11]	Gleicher N, Weghofer A, Barad DH . Defining ovarian reserve to better understand ovarian aging. Reprod Biol Endocrinol, 2011,9:23.
[12]	Sills ES, Alper MM, Walsh AP . Ovarian reserve screening in infertility: practical applications and theoretical directions for research. Eur J Obstet Gynecol Reprod Biol, 2009,146(1):30-36.
[13]	May-Panloup P, Boucret L, Chao de la Barca JM, Desquiret-Dumas V, Ferré-L'Hotellier V, Morinière Descamps P, Procaccio V, Reynier P. Ovarian ageing: the role of mitochondria in oocytes and follicles. Hum Reprod Update, 2016,22(6):725-743.
[14]	Wilding M, Dale B, Marino M, di Matteo L, Alviggi C, Pisaturo ML, L

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Advances in the study of ovarian dysfunction with aging

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments