线粒体代谢介导的表观遗传改变与衰老研究

doi:10.16288/j.yczz.19-065

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (10): 893-904.doi: 10.16288/j.yczz.19-065

• Review • Next Articles

Mitochondrial metabolism’s effect on epigenetic change and aging

Yunfeng Pan,Yanyi Wang,Jingwen Chen,Yimei Fan()

Medical School, Nanjing University, Nanjing 210093, China

Received:2019-04-08 Revised:2019-06-08 Online:2019-10-20 Published:2019-06-10
Contact: Fan Yimei E-mail:ymfan@nju.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China No.(81771504)

Abstract

Abstract:

Mitochondrion is the metabolic center and powerhouse of cells producing cellular energy which plays an important role in various physiological and pathophysiological processes. Recent research demonstrates that mitochondrial energy metabolism mediates the transmission of mitochondrial-nuclear signals through intermediate products which regulates epigenetic presentation of the chromatin and thereby affects gene expression. Epigenetic modification, a genetic regulatory model, is independent of DNA sequence and plays a major role in establishing and maintaining a specific gene’s expression profile. Disorders of mitochondrial metabolism can induce epigenetic reprogramming which in turn initiates aging phenotypes and degenerative diseases. This review introduces recent research progress on the relationship between mitochondrial metabolism and chromatin-related epigenetic modification, discusses the role of mitochondrial stress in chromatin recombination, and suggests future research directions and their application in the study of age-related diseases such as cognitive dysfunction.

Key words: mitochondrial metabolism, DNA methylation, histone modifications, aging, UPR ^mt

Yunfeng Pan, Yanyi Wang, Jingwen Chen, Yimei Fan. Mitochondrial metabolism’s effect on epigenetic change and aging[J]. Hereditas(Beijing), 2019, 41(10): 893-904.

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