细胞重编程过程中核小体定位改变研究进展

doi:10.16288/j.yczz.21-299

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Hereditas(Beijing) ›› 2022, Vol. 44 ›› Issue (3): 208-215.doi: 10.16288/j.yczz.21-299

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Progress on the study of nucleosome reorganization during cellular reprogramming

Haoliang Cui(), Peihua Shi, Jinchun Gao, Xinbo Zhang, Shunran Zhao, Chenyu Tao()

College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China

Received:2021-08-13 Revised:2022-01-07 Online:2022-03-20 Published:2022-02-24
Contact: Tao Chenyu E-mail:1522942442@qq.com;taochenyuty@163.com
Supported by:
Supported by the National Natural Science Foundation of China(31802063);Natural Science Foundation of Hebei Province No.(C2020204058);Scientific Research Foundation for the Introduction of Talent in Hebei Agricultural University No(ZD201718)

Abstract

Abstract:

Cellular reprogramming is the process during which epigenetic markers of nuclear genome are deleted and remodeled during sperm-egg binding or nuclear transplantation, thereby rendering differentiated cells totipotent. The main cellular reprogramming methods are cell fusion, somatic cell nuclear transplantation, and induced pluripotent stem cells. Nucleosomes are the basic structural and functional units of chromatin, and nucleosome localization has an important role in regulating gene expression and the state of the cell. The occupancy and location of nucleosomes also change dramatically during cellular reprogramming, while the occupancy of nucleosomes around the transcriptional start site also decreases to promote the expression of pluripotency genes. In this review, we summarize the role of nucleosome localization in gene activation and repression, chromatin remodeling, and transcription factor recognition, with the aim of providing an important basis for an in-depth analysis of cellular reprogramming mechanisms.

Key words: cellular reprogramming, nucleosome localization, chromatin remodeling, transcription initiation sites

Haoliang Cui, Peihua Shi, Jinchun Gao, Xinbo Zhang, Shunran Zhao, Chenyu Tao. Progress on the study of nucleosome reorganization during cellular reprogramming[J]. Hereditas(Beijing), 2022, 44(3): 208-215.

Figures/Tables 3

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