表观遗传修饰对脂肪组织产热的调控进展

doi:10.16288/j.yczz.22-151

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Hereditas(Beijing) ›› 2022, Vol. 44 ›› Issue (10): 867-880.doi: 10.16288/j.yczz.22-151

• Review • Previous Articles Next Articles

Progress on the epigenetic regulation of adipose tissue thermogenesis

Qingwen Zhao¹(), Dongning Pan²()

1. Department of Geriatrics, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
2. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, China

Received:2022-05-09 Revised:2022-07-22 Online:2022-10-20 Published:2022-08-11
Contact: Pan Dongning E-mail:17111010048@fudan.edu.cn;dongning.pan@fudan.edu.cn
Supported by:
the Fellowship of China Postdoctoral Science Foundation(2020M680053);the National Natural Science Foundation of China(31970710)

Abstract

Abstract:

The activation of brown adipose tissues and beige adipose tissues can utilize more substrates, including glucose and fatty acids, regulate the energy balance of the whole body and improve metabolic diseases such as obesity and type Ⅱ diabetes. Elucidating the regulatory mechanisms underlying the thermogenic adipose program may provide excellent targets for therapeutics against metabolic diseases. The current studies have indicated that epigenetic modifications are vital for regulating differentiation and thermogenesis of adipose tissues. In this review, we summarize the recent progress of epigenetic modifications in adipose tissue development and thermogenesis from the aspects of DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs in order to provide new ideas for further studying the activation of adipose tissues.

Key words: epigenetic modifications, brown adipose tissues, beige adipose tissues, browning, thermogenesis

Qingwen Zhao, Dongning Pan. Progress on the epigenetic regulation of adipose tissue thermogenesis[J]. Hereditas(Beijing), 2022, 44(10): 867-880.

Figures/Tables 3

Table 1

Fig. 1

Fig. 2

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表观修饰	酶的名称	染色质标记	功能	参考文献
DNA甲基化	DNMT1/DNMT3A	DNA甲基化	促进分化	[12]
DNA甲基化	DNMT3B	DNA甲基化	抑制产热、促进分化	[13,14]
DNA去甲基化	TET1/2/3	DNA去甲基化	促进分化、促进产热、抑制米色化	[15~17]
组蛋白乙酰化	GCN5/PCAF	H3K9Ac	促进米色化、促进分化	[18,19]
组蛋白乙酰化	CBP/p300	H3K27Ac	促进分化	[20]
组蛋白去乙酰化	HDAC1	H3K27Ac	抑制产热	[21,22]
	HDAC3	H3K27Ac、去乙酰化非组蛋白	抑制产热、抑制米色化、促进产热	[23~25]
	HDAC9	H3K27Ac	抑制米色化	[26]
	SIRT1	H3K9Ac、H4K16Ac、去乙酰化非组蛋白	抑制分化、促进米色化	[27~29]
	SIRT2	H3K9Ac	抑制分化	[30]
	SIRT5	H3K9Ac	促进米色化	[31]
	SIRT6	H3K9Ac	促进分化、促进产热	[32,33]
	SIRT7	H3K9Ac、H4K16Ac	促进分化	[34]
组蛋白甲基化	MLL3/4	H3K4me1/me2	促进分化、促进产热	[353637]
	EHMT1	H3K9me1/me2	促进分化	[38]
	EHMT2	H3K9me2	抑制分化	[39,40]
	EZH2	H3K27me3	促进分化、抑制分化	[41,42]
	NSD2	H3K36me1/me2	促进分化	[43]
	KMT5B/KMT5C	H4K20me3	抑制产热、促进产热	[44,45]
组蛋白去甲基化	LSD1	H3K4me1/me2、H3K9me1/me2	促进分化、促进氧化磷酸化、促进产热	[46,47,48,49]
	KDM3A	H3K9me1/me2	促进产热	[50,51]
	KDM6A	H3K27me3	促进分化、促进产热	[12,52]
	KDM6B	H3K27me3	促进产热	[53]

Progress on the epigenetic regulation of adipose tissue thermogenesis

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