双亮氨酸拉链激酶DLK对JNK信号通路的调控作用及机制

doi:10.3724/SP.J.1005.2010.00785

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (8): 785-790.doi: 10.3724/SP.J.1005.2010.00785

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Regulation of the JNK signaling pathway by dual leucine zipper kinase DLK

MA Xian-Jue, XUE Lei

School of Life Science and Technology, Tongji University, Shanghai 200092, China

Received:2009-11-10 Revised:2010-03-28 Online:2010-08-20 Published:2010-08-23
Contact: XUE Lei E-mail:lei.xue@tongji.edu.cn

Abstract

Abstract: The C-Jun NH₂-terminal kinase (JNK) belongs to the evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases family. Many studies have shown that JNK pathway plays physiological roles in cell proliferation, differentiation, migration and apoptosis, and its deregulation has been associated with developmental defects and various human diseases. Dual leucine zipper kinase (DLK) is a member of the mixed-lineage kinases that performs important cellu-lar functions as a MAP triple kinase (MAPKKK) in regulating the JNK signaling pathway. In this paper, we described the DLK protein structures, physiological roles, and their functional interactions with JNK signaling, as well as the molecular mechanisms underlying their involvement in various human diseases.

Key words: JNK, DLK, signal transduction pathway

MA Xian-Jue, XUE Lei. Regulation of the JNK signaling pathway by dual leucine zipper kinase DLK[J]. HEREDITAS, 2010, 32(8): 785-790.

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Regulation of the JNK signaling pathway by dual leucine zipper kinase DLK

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