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HEREDITAS ›› 2010, Vol. 32 ›› Issue (11): 1133-1140.doi: 10.3724/SP.J.1005.2010.01133

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Molecular basis and applicability in equine color genetics

LI Bei1, HE Xiao-Long3, ZHAO Yi-Ping1, WANG Xiao-Jing1, Dugarjaviin Manglai2, ZHANG Yan-Ru2   

  1. 1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
     2. College of Life Science, Inner Mongolia Agricultural University, Hohhot 010018, China, 
    3. Inner Mongolia Academy of Agriculture and Animal Sciences, Hohho, 010031, China
  • Received:2010-02-11 Revised:2010-04-19 Online:2010-11-20 Published:2010-11-25
  • Contact: Dugarjaviin Manglai,ZHANG Yan-Ru E-mail:dmanglai@yahoo.com.cn;yanru1964@163.com

Abstract: Coat color can be used not only in identifying individuals and species, but also in diagnosing certain diseases. The coat color of horse mainly denpends on the distribution and proportion of eumelanin and phaeomelanin, generated by melanocytes, which are regulated by the genes such as MC1R, ASIP, KIT, TYRP, and EDNRB. In addition, STX17, MATP, and PMEL17 also play a role in the formation of coat color of horse. In this review, the action mechanism of candidate genes for coat color and association of DNA sequence polymorphism of these candidate genes with color pattern pheno-types and melanoma were summarized in details, which provides efficient theoretical support for horse breeding and control of the horse diseases.

Key words: horse, coat colour pattern, candidate gene, melanoma