真菌类过氧化物酶体增殖因子PEX11基因家族生物信息学研究

doi:10.3724/SP.J.1005.2012.00635

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HEREDITAS ›› 2012, Vol. 34 ›› Issue (5): 635-646.doi: 10.3724/SP.J.1005.2012.00635

Bioinformaticresearch of the family of PEX11, peroxisomeproliferous factor in fungus

ZHANG Xin^1,2, JIANG Hua², WANG Yan-Li², ZHANG Zhen², MAO Xue-Qin², CHAI Rong-Yao², QIU Hai-Ping², DU Xin-Fa², WANG Jiao-Yu², SUN Guo-Chang²

1. College of Life and Environment Sciences, Hangzhou Normal University, Hangzhou 310036, China 2. State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection Microbiology, Zhejiang Academy of Agricultural sciences, Hangzhou 310021, China

Received:2011-08-18 Revised:2011-10-24 Online:2012-05-20 Published:2012-05-25

Abstract

Abstract: The family members of PEX11 are key factors involved in regulation of peroxisome proliferation. Sixty-six PEX11p candidates of PEX11 gene family from26 representative fungal species were obtainedand analyzed by bioinformatic strategies. In most filamentous fungi, 2 or 3 potential PEX11ps were found, in contrast with 1 or 2 in yeast species. Com-pared with other fungal species, the Ascomycetes tend to have more PEX11ps, and even 5 in several individuals. The data of phylogenetic analysis and protein structure indicated that all of the PEX11ps were divided into 3groups: I, II, and III. The members of group I and groupIIIexisted in most species, while those in group II were found only in Pezizomycotina. By MEME analysis, 5-6 conserved motifs were found in each PEX11ps. Among them,motif 8 in C-terminal had the most conservation, indicating that this motif probably plays a key role in maintaining the proper functionof PEX11p.

Key words: PEX11 gene family, bioinformatics, phylogenetic analysis, fungus, peroxisome

ZHANG Xin, JIANG Hua, WANG Yan-Li, ZHANG Zhen, MAO Xue-Qin, CHAI Rong-Yao, QIU Hai-Ping, DU Xin-Fa, WA Jiao-Yu, SUN Guo-Chang. Bioinformaticresearch of the family of PEX11, peroxisomeproliferous factor in fungus[J]. HEREDITAS, 2012, 34(5): 635-646.

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Bioinformaticresearch of the family of PEX11, peroxisomeproliferous factor in fungus

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