蛋白质泛素化修饰的生物信息学研究进展

doi:10.3724/SP.J.1005.2013.00017

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HEREDITAS ›› 2013, Vol. 35 ›› Issue (1): 17-26.doi: 10.3724/SP.J.1005.2013.00017

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Bioinformatics advances in protein ubiquitination

LU Liang, LI Dong, HE Fu-Chu

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China

Received:2012-04-28 Revised:2012-06-20 Online:2013-01-20 Published:2013-01-25

Abstract

Abstract: Ubiquitin-proteasome system (UPS) mediates 80% to 85% of the protein degradation in eukaryotic cells. The characteristics of UPS pathway are dependent on ATP, efficient and highly selective. Ubiquitination not only participates in protein degradation, but also directly affects protein activity and localization. Ubiquitination can regulate multiple cellular processes including cell cycle progression, apoptosis, transcriptional regulation, DNA damage repair and immune response. More and more datasets about UPS are published, and it is necessary to organize and analyze these data efficiently. We re-view the related bioinformatics studies in UPS datasets, such as collection of UPS related proteins, construction and analy-sis of ubiquitination networks, prediction of ubiquitination sites and motifs. Some potential perspectives are also discussed.

Key words: Ubiquitin-proteasome system (UPS), ubiquitination, bioinformatics

LU Liang LI Dong HE Fu-Chu. Bioinformatics advances in protein ubiquitination[J]. HEREDITAS, 2013, 35(1): 17-26.

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