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HEREDITAS ›› 2006, Vol. 28 ›› Issue (11): 1451-1456.doi: 10.1360/yc-006-1451

• 专论与综述 • Previous Articles     Next Articles

Progress in the Study of KRAB Zinc Finger Protein

TIAN Chun-Yan; ZHANG Ling-Qiang; HE Fu-Chu   

  1. Laboratory of Systems Biology, Institute of Radiation Medicine, Beijing 100850, China
  • Received:2005-11-17 Revised:2006-08-17 Online:2006-11-05 Published:2006-11-05
  • Contact: HE Fu-Chu

Abstract:

The zinc finger proteins containing the Kruppel-associated box domain (KRAB) constitute the largest single family of transcriptional regulators in mammals. Many genes encoding members of this family are arranged in clusters. KRAB-containing proteins are characterized by the presence of 4 and over 30 C2H2 zinc-finger motifs and a KRAB domain near the amino terminus of the protein. KRAB domain behaving as a protein-protein interaction domain could bind to corepressor proteins and/or transcription factors, and that the KRAB-containing proteins could act as a repressor or corepressor and play a key role in transcriptional repression. Members of the family are involved in embryonic development, cell differentiation, cell proliferation, apoptosis, neoplastic transformation and cell cycle regulation.

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