染色质构象调控真核基因的表达

doi:10.3724/SP.J.1005.2011.01291

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (12): 1291-1299.doi: 10.3724/SP.J.1005.2011.01291

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Role of chromatin conformation in eukaryotic gene regulation

QI He-Yuan^1,2, ZHANG Zhao-Jun¹, LI Ya-Juan¹, FANG Xiang-Dong¹

1. Laboratory of Disease Genomics and Personalized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China 2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Received:2011-07-20 Revised:2011-09-14 Online:2011-12-20 Published:2011-12-25

Abstract

Abstract: Gene expression in eukaryotes is regulated at multiple levels, which involves various cis-regulatory elements and trans-acting factors at transcriptional level. In addition, DNA methylation and histone modifications also play crucial roles in epigenetic regulation of eukaryotic genes. It is pivotal for evaluating the regulation of gene expression to understand the structural properties and spatial organization of chromatin at 3-D level. The dynamic alternations of chromatin confor-mation can either activate gene expression by facilitating the interactions between enhancers or other cis-regulatory elements and their target genes or suppress gene expression by blocking the interactions due to steric hindrance. Although the precise molecular mechanisms underlying the gene regulation via conformational changes of chromatin remain obscure, epigenetic studies including histone modification, nucleosome positioning, chromosome territories as well as chromatin interactions, have provided accumulating evidence to demonstrate the significance of chromatin conformation in eukaryotic gene regulation. Here, we reviewed the recent advances on the role of dynamic alterations of chromatin in gene regulation , which occur at different levels from the primary structure to three dimensional conformation.

Key words: chromatin conformation, gene regulation, epigenetics

CLC Number:

Q756

QI He-Yuan, ZHANG Zhao-Jun, LI Ya-Juan, FANG Xiang-Dong. Role of chromatin conformation in eukaryotic gene regulation[J]. HEREDITAS, 2011, 33(12): 1291-1299.

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