Myomaker和Myomerger调控成肌细胞融合的分子机制

doi:10.16288/j.yczz.19-232

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (12): 1110-1118.doi: 10.16288/j.yczz.19-232

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Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion

Yan Zhu¹, Jinwei Zhang¹, Jing Qi¹, Xuewei Li¹, Lei Chen², Mingzhou Li¹, Jideng Ma¹()

^1. Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
^2. Chongqing Academy of Animal Sciences, Chongqing 402460, China

Received:2019-08-08 Revised:2019-10-25 Online:2019-12-20 Published:2019-12-05
Contact: Ma Jideng E-mail:jideng.ma@sicau.edu.cn
Supported by:
Supported by Research and Development Project of Scientific and Technological Cooperation between Sichuan Provincial Colleges and Universities No(2017JZ0025);the Science and Technology Support Program of Sichuan Nos(2016NYZ0042);the Science and Technology Support Program of Sichuan Nos.(2017NZDZX0002);Chongqing Agricultural Development Foundation Nos(12404);Chongqing Agricultural Development Foundation Nos(17430);the Key Research and Development Projects of Sichuan Science and Technology Department No(2019YFN0035)

Abstract

Abstract:

Myogenesis is a complex physiological process that is mainly involved in the proliferation of myogenic stem cells to form myoblasts, which then differentiated and fused to form multinucleated myotubes. Many proteins have been found to be involved in myoblast fusion, but none of them are muscle-specific fusion proteins. In recent years, two muscle-specific transmembrane proteins, i.e. Myomaker and Myomerger, have been discovered and identified, which can coordinate and promote the fusion of myoblasts and thus participate in the process of myogenesis. In this review, we summarize the research progress of Myomaker and Myomerger in myogenesis, including their expression patterns and functional domains, as well as their participation in myoblast fusion mechanisms, aiming to provide relevant ideas for in-depth study of the myogenesis process and treatment of diseases related to myoblast fusion.

Key words: myogenesis, Myomaker, Myomerger, myoblast fusion

Yan Zhu, Jinwei Zhang, Jing Qi, Xuewei Li, Lei Chen, Mingzhou Li, Jideng Ma. Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion[J]. Hereditas(Beijing), 2019, 41(12): 1110-1118.

Figures/Tables 4

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Table 1

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基因	物种	染色体位置	可变剪接体数	转录ID	外显子数	转录长度 (bp)	翻译长度 (aa)	参考文献
Myomaker	小鼠 (M. musculus)	Chr.2:27061636-27072179	2	ENSMUST00000009358.2	5	1382	221	[5~7,29]
	小鼠 (M. musculus)	Chr.2:27061636-27072179	2	ENSMUST00000163967.1	5	1210	180	[5~7,29]
	人 (H. sapiens)	Chr.9:136379708-136393734	2	ENST00000339996.3	5	818	221	[28]
	人 (H. sapiens)	Chr.9:136379708-136393734	2	ENST00000413714.1	0	531	-	[28]
	斑马鱼 (D. rerio)	Chr.5:68934948-68940186	2	ENSDART00000033962.6	5	663	220	[23]
	斑马鱼 (D. rerio)	Chr.5:68934948-68940186	2	ENSDART00000138519.1	1	258	45	[23]
	鸡 (G. gallus)	Chr.17:6958313-6965254	1	ENSGALT00000034784.3	5	1078	220	[27]
Myomerger	小鼠 (M. musculus)	Chr.17: 45600967-45602102	3	ENSMUST00000113529.2	1	811	84	[8,9,25]
				ENSMUST00000169137.1	2	852	18
				ENSMUST00000178858.1	1	808	84
	大鼠 (R. norvegicus)	Chr.9: 16670994-16671263	1	ENSRNOT00000064497.2	1	270	89	-
	人 (H. sapiens)	Chr.6: 44216939-44218236	2	ENST00000573382.2	1	817	84	-
	人 (H. sapiens)	Chr.6: 44216939-44218236	2	ENST00000576476.1	1	682	84	-

Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion

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