泛素化途径在奶牛乳脂生成过程中的调控作用

doi:10.16288/j.yczz.20-037

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (6): 548-555.doi: 10.16288/j.yczz.20-037

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The regulation of ubiquitination in milk fat synthesis in bovine

Lili Liu¹, Aiwei Guo¹, Qingqing Li^1,², Peifu Wu¹, Yajin Yang¹, Fenfen Chen¹, Suhua Li¹, Panjiang Guo¹, Qin Zhang³

^1. College of Life Science, Southwest Forestry University, Kunming 650224, China
^2. Kunming Xianghao Technology Co. Ltd., Kunming 650204, China
^3. College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271000, China

Received:2020-02-10 Revised:2020-04-15 Online:2020-06-20 Published:2020-05-07
Supported by:
Supported by the National Natural Science Foundation of China Nos(31902152);Supported by the National Natural Science Foundation of China Nos(31872327)

Abstract

Abstract:

Ubiquitination signaling is the main pathway of protein degradation in eukaryotic cells. Ubiquitin-proteasome system degrades the ubiquitinated cytoplasmic proteins and lysosome pathway mainly degrades the ubiquitinated membrane proteins. Previous studies have shown that ubiquitination signaling plays a critical role in fatty acids synthesis. In the process of fatty acids import, disruption of ubiquitination could prevent the degradation of fatty acid transport proteins, thereby promoting fatty acids import and milk fat synthesis in bovine primary mammary epithelial cells. In this review, we summarize the signal transduction and regulation mechanism of ubiquitination signaling in milk fat synthesis, which may provide references and new ideas for future research on milk fat traits in dairy cows.

Key words: ubiquitination, ubiquitinated-proteasome system, lysosome pathway, milk fat synthesis, fatty acid

Lili Liu, Aiwei Guo, Qingqing Li, Peifu Wu, Yajin Yang, Fenfen Chen, Suhua Li, Panjiang Guo, Qin Zhang. The regulation of ubiquitination in milk fat synthesis in bovine[J]. Hereditas(Beijing), 2020, 42(6): 548-555.

Figures/Tables 3

References 65

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