幽门螺杆菌毒力基因分型和宿主遗传多态性与胃病关系研究进展

doi:10.3724/SP.J.1005.2011.00558

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (6): 558-566.doi: 10.3724/SP.J.1005.2011.00558

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Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics

ZHANG Li^1,2, WANG Peng¹, WEI Sha-Li², LIU Chun-Jie¹

1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing 100071, China 2. Public Healith of Chongqing Medical University, Chongqing 400016, China

Received:2010-09-30 Revised:2011-01-14 Online:2011-06-20 Published:2011-06-25
Contact: LIU Chun-Jie E-mail:liucj@nic.bmi.ac.cn

Abstract

Abstract: Helicobacter pylori infection may cause many gastric disease, such as peptic ulcers, chronic atrophic gastritis, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer. The different clinical outcomes of Helicobacter pylori infection are related to H. pylori virulence factors and host gene polymorphism. H.pylori had been confirmed to be the class I carcinogen by the World Health Organization and International Agency for Research on Cancer Consensus Group (IARC) in1994. Most severe diseases always occur in the background that certain microbial virulence markers (e.g. cagA, vacA) and susceptible host genetic polymorphisms harboured together. Herein, we reviewed the association with H. pylori-related gastric diseases in relation to diffirent H. pylori types and the host polymorphisms.

Key words: Helicobacter pylori, genotype, gene polymorphism, gastritis, gastric cancer, ulcer, host

ZHANG Li, WANG Peng, WEI Sha-Chi, LIU Chun-Jie. Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics[J]. HEREDITAS, 2011, 33(6): 558-566.

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Advances in relationship between gastric disease and polymorphisms in both helicobacter pylori virulence factors and host genetics

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