肾脏发育中信号通路的调控作用

doi:10.16288/j.yczz.2015.01.001

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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (1): 1-7.doi: 10.16288/j.yczz.2015.01.001

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The roles of signaling pathways in regulating kidney development

Xiao Qiu^{1, 2}, Rongfei Wei^{1, 2}, Lingqiang Zhang², Fuchu He^{1, 2}

1. School of Life Sciences, Tsinghua University, Beijing 100089, China; 2. State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China

Received:2014-07-26 Revised:2014-10-15 Online:2015-01-20 Published:2015-01-20

Abstract

Abstract: The development of mammalian kidney is a complex process. The reciprocal inductive interactions between epithelial cells and metanephric mesenchymal cells determine cell fates including proliferation, growth, apoptosis, and eventually contribute to the formation of an intact kidney. Multiple signaling pathways, including the GDNF/Ret, Wnt and BMP signaling pathways, have been shown to regulate the development of kidney. A myriad of signaling pathways and their cross-talks form a precise spatiotemporal regulatory network, which ensures the kidney to be properly organized. In this review, we summarize the physiological process of kidney development as well as the involved signaling pathways and their interplay.

Key words: kidney development, GDNF/Ret, Wnt, BMP, FGF, Notch

Xiao Qiu, Rongfei Wei, Lingqiang Zhang, Fuchu He. The roles of signaling pathways in regulating kidney development[J]. HEREDITAS(Beijing), 2015, 37(1): 1-7.

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The roles of signaling pathways in regulating kidney development

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