绵羊FecB突变对BMPR1B活性及BMP/SMAD通路的影响研究进展

doi:10.16288/j.yczz.22-366

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (4): 295-305.doi: 10.16288/j.yczz.22-366

• Review • Previous Articles Next Articles

Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep

Yiming Gong(), Xiangyu Wang, Xiaoyun He, Yufang Liu, Ping Yu, Mingxing Chu(), Ran Di()

Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2022-11-17 Revised:2023-02-06 Online:2023-04-20 Published:2023-03-28
Contact: Chu Mingxing,Di Ran E-mail:g18080010835@163.com;dirangirl@163.com;mxchu@263.net
Supported by:
National Natural Science Foundation of China(32272838);National Natural Science Foundation of China(31861143012);Earmarked Fund for China Agriculture Research System of MOF and MARA(CARS-38);Agricultural Science and Technology Innovation Program of China(CAAS-ZDRW202106);Agricultural Science and Technology Innovation Program of China(ASTIP-IAS13)

Abstract

Abstract:

BMPR1B is the first major gene of litter size identified in sheep. However, the molecular mechanism of the FecB mutation that increases the ovulation rate in sheep is still unclear. In recent years, it has been demonstrated that BMPR1B activity is regulated by the small molecule repressor protein FKBP1A, which acts as a key activity switch of the BMPR1B in the BMP/SMAD pathway. The FecB mutation is located close to the binding site of FKBP1A and BMPR1B. In this review, we summarize the structure of BMPR1B and FKBP1A proteins, and clarify the spatial interactive domains of the two proteins with respect to the location of the FecB mutation. Then the relationship between the FecB mutation and the degree of affinity of the two proteins are predicted. Finally, the hypothesis that FecB mutation causes change of activity in BMP/SMAD pathway by affecting the intensity of the interactions between BMPR1B and FKBP1A is proposed. This hypothesis provides a new clue to investigate the molecular mechanism of FecB mutation affecting ovulation rate and litter size in sheep.

Key words: sheep, FecB mutation, BMPR1B, FKBP1A, BMP/SMAD pathway

Yiming Gong, Xiangyu Wang, Xiaoyun He, Yufang Liu, Ping Yu, Mingxing Chu, Ran Di. Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep[J]. Hereditas(Beijing), 2023, 45(4): 295-305.

Figures/Tables 5

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Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep

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