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Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (7): 546-560.doi: 10.16288/j.yczz.18-077

• Reviews • Previous Articles     Next Articles

Acid-resistant genes in Mycobacterium tuberculosis and the underlying regulatory network

Liyuan Zhang,Fujing Huang,Junqi Xu,Zhen Gong,Jianping Xie()   

  1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China
  • Received:2018-03-27 Revised:2018-05-08 Online:2018-07-20 Published:2018-05-31
  • Supported by:
    Supported by the National Undergraduate Training Programs for Innovation and Entrepreneurship of China(201710635064);Teaching Reform Project of Chongqing Municipal Education Commission(163024);Teaching Reform Project of Southwest University(2016JY050)

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Abstract:

The molecular mechanisms of pathogen persistence within host cells are emerging hotspots, and one of the causes of its persistence is the acid resistance of bacteria. Currently, tuberculosis remains a serious threat to global public health and it is caused by Mycobacterium tuberculosis. In particular, acid resistance of M. tuberculosis and its persistence within macrophages contribute significantly to tuberculosis. Investigations have uncovered three major mechanisms underlying its acid resistance: the control of proton entry, metabolic regulation of intracellular acid-base balance and regulation of the two-component signaling system. In this review, we summarize the overall regulation network of M. tuberculosis in the acidic environment, aiming at providing a new overall idea for treating M. tuberculosis persistence and exploring new targets for tuberculosis control.

Key words: Mycobacterium tuberculosis, acid-resistance related gene, retention, regulatory network