固醇调节元件结合蛋白1及其靶基因网络

doi:10.3724/SP.J.1005.2013.00607

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HEREDITAS ›› 2013, Vol. 35 ›› Issue (5): 607-615.doi: 10.3724/SP.J.1005.2013.00607

Sterol regulatory element binding protein 1 and its target gene networks

TANG Xiao-Li^1,2, DENG Li-Bin³, LIN Jia-Ri³, ZHANG Wei-Long³, LIU Shuang-Mei¹, WEI Yi³, MEI Pu-Ming³, WANG Yan³, LIANG Shang-Dong¹

1. Department of Physiology, Medical College of Nanchang University, Nanchang 330001, China 2. Department of Biochemistry, Medical College of Nanchang University, Nanchang 330001, China 3. Institute of Translational Medicine of Nanchang University, Nanchang 330001, China

Received:2012-09-27 Revised:2012-10-23 Online:2013-05-20 Published:2013-05-25

Abstract

Abstract: Sterol regulatory element binding protein 1 (SREBP-1) is one of the important nuclear transcription factors. SREBP-1 can maintain lipids dynamic equilibrium by regulating the expression of enzymes required for synthesis of endogenous cholesterol, fatty acids, triglycerides and phospholipids. Anomalies of SREBP-1 and its target genes can cause a series of metabolic diseases such as insulin resistance, type Ⅱ diabetes, heart dysfunction, vascular complications and hepatic steatosis. In these years, the development of high-throughput technologies has greatly expanded our knowledge about SREBP-1 target genes and the pattern of transcriptional regulation. Here we reviewed recent research progress of SREBP-1, with a focus on the protein structure, activation process, DNA binding sites and target genes. Most importantly, we showed the transcriptional regulatory networks based on omics datasets, which will contribute to a better understanding of the role of SREBP-1 in lipid metabolism and provide new clues for the treatment of lipid metabolism disorders.

Key words: sterol regulatory element binding protein 1, target genes, gene regulatory networks, lipid metabolism

TANG Xiao-Li DENG Li-Bin LIN Jia-Ri ZHANG Wei-Long LIU Shuang-Mei WEI Yi MEI Pu-Ming WANG Yan LIANG Shang-Dong. Sterol regulatory element binding protein 1 and its target gene networks[J]. HEREDITAS, 2013, 35(5): 607-615.

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Sterol regulatory element binding protein 1 and its target gene networks

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