秀丽隐杆线虫固有免疫功能神经调控机制研究进展

doi:10.16288/j.yczz.18-133

[an error occurred while processing this directive]

Hereditas(Beijing) ›› 2018, Vol. 40 ›› Issue (12): 1066-1074.doi: 10.16288/j.yczz.18-133

• Reviews • Previous Articles Next Articles

Progress in the mechanisms of neural modulation of innate immunity in Caenorhabditis elegans

Xiumei Zhang¹,Jie Gao¹,Chunhong Chen^1,²,Haijun Tu^1,²()

^1. Institute of Neuroscience, College of Biology, Hunan University, Changsha 410082, China
^2. Shenzhen Research Institute, Hunan University, Shenzhen 518000, China

Received:2018-05-15 Revised:2018-06-26 Online:2018-12-20 Published:2018-09-11
Contact: Tu Haijun E-mail:haijuntu@hnu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(31540020);Supported by the National Natural Science Foundation of China(31671048);the Free Exploration Foundation of Shenzhen Science and Technology Innovation Committee(JCYJ20160530192506314);the Provincial Natural Science Foundation of Hunan Province(2017JJ2041)

Abstract

Abstract:

The innate immune system is an important defense barrier against invasive microbial threats in plants and animals. The nematode worm Caenorhabditis elegans is a classic model to investigate the genetic and cellular mechanisms of the interaction between host and pathogens. In the past years, many studies have elucidated the machinery of host-pathogen interactions using C. elegans. Neurons secrete/release neuropeptides and neurotransmitters such as NLP-20 and dopamine, which in turn mediate microbial recognition, promote pathogen avoidance, activate innate immune response signaling to stimulate antimicrobial peptide expression and kill microbes, and ultimately protect organisms from pathogen infection. In this review, we summarize the recent advances in the mechanisms of neural modulation of innate immunity in C. elegans, which provide important knowledge not only for machinery of functional interaction between nervous and immune system, but also for pathological mechanisms of nervous and immune system related diseases.

Key words: Caenorhabditis elegans, neuron, innate immunity, neurotransmitter, antimicrobial peptide

Xiumei Zhang, Jie Gao, Chunhong Chen, Haijun Tu. Progress in the mechanisms of neural modulation of innate immunity in Caenorhabditis elegans[J]. Hereditas(Beijing), 2018, 40(12): 1066-1074.

References

[1]	Wu QL, Cao X, Dong Y, Wang DY, Aballay A . Genetic screen reveals link between the maternal effect Sterile gene mes-1 and pseudomonas aeruginosa-induced neurodegeneration in Caenorhabditis elegans . J Biol Chem, 2015,290(49):29231-29239.
[2]	Sun LM, Liao K, Hang CC, Wang DY . Honokiol induces reactive oxygen species-mediated apoptosis in Candida albicans. PLoS One, 2017,12(2):e0172228.
[3]	Kurz CL, Ewbank JJ . Caenorhabditis elegans: an emerging genetic model for the study of innate immunity. Nat Rev Genet, 2003,4(5):380-390.
[4]	Yu YL, Zhi LT , Wu QL Jing LN,Wang DY. NPR-9 regulates the innate immune response in Caenorhabditis elegans. Cell Mol Immunol, 2016,15(1):27-37.
[5]	Zhi LT, Yu YL, Li XY, Wang DY, Wang DY . Molecular control of innate immune response to Pseudomonas aeruginosa infection by Intestinal let-7 in Caenorhabditis elegans. PLoS Pathog, 2017,13(1):e1006152.
[6]	Sifri CD, Begun J, Ausubel FM . The worm has turned - microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol, 2005,13(3):119-127.
[7]	Engelmann I, Pujol N . Innate immunity in C. elegans . Adv Exp Med Biol, 2010,708:105-121.
[8]	Besedovsky HO, del Rey A . Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev, 1996,17(1):64-102.
[9]	Schulenburg H, Kurz CL, Ewbank JJ . Evolution of the innate immune system: the worm perspective. Immunol Rev, 2004,198:36-58.
[10]	Besedovsky H, Sorkin E, Felix D, Haas H . Hypothalamic changes during the immune response. Eur J Immunol, 1977,7(5):323-325.
[11]	Sternberg EM . Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol, 2006,6(4):318-328.
[12]	Bilbo SD, Klein SL . Special Issue: the neuroendocrine- immune axis in health and disease. Horm Behav, 2012,62(3):187-190.
[13]	Kim DH, Ausubel FM . Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans . Curr Opin Immunol, 2005,17(1):4-10.
[14]	Kim DH, Ausubel FM . Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans . Curr Opin Immunol, 2005,17(1):4-10.
[15]	Nicholas HR, Hodgkin J . Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans . Mol Immunol, 2004,41(5):479-493.
[16]	Kim D . Studying host-path

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Progress in the mechanisms of neural modulation of innate immunity in Caenorhabditis elegans

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments