中枢单胺类神经递质在酒精依赖中的分子作用机制

doi:10.3724/SP.J.1005.2014.00011

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HEREDITAS ›› 2014, Vol. 36 ›› Issue (1): 11-20.doi: 10.3724/SP.J.1005.2014.00011

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Alcohol dependence mediated by monoamine neurotransmitters in the central nervous system

Xiaohua Yang¹, Huafeng Zhang², Jianghua Lai¹

1. Key Laboratory of Ministry of Health for Forensic Sciences, School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China;
2. College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710062, China

Received:2013-08-22 Revised:2013-10-19 Online:2014-01-20 Published:2013-12-20

Abstract

Abstract:

Alcohol dependence, a chronic relapsing brain disease with the characteristics of drinking alcohol out of control, has become a serious social problem. Monoamine neurotransmitters, mainly including dopamine and 5-hydroxytryp¬tamine, play important roles in the occurrence, development and neural dysfunction of alcohol dependence syndrome. In this review, the roles of key factors of the monoamine system (dopamine receptor genes, 5-hydroxytryptamine receptor genes, transporter genes, tyrosine hydroxylase gene, tryptophanhydroxylase gene and monoamine oxidase gene) in alcohol dependence were discussed, and strategies for further studies of molecular mechanisms were proposed based on gene knockout mice models generated in our laboratory. Then, combining with studies on tyrosine hydroxylase activator CaMKII in our lab, therapeutic targets were discussed. Besides, epigenetic strategies for prevention and treatment of alcohol dependence syndrome were proposed. Furthermore, manipulating methylation levels in gene regulatory regions and alternative splicing of pre-mRNAs might also have clinical implications. Finally, based on new findings on genetic polymorphism, it is of great potential to carry out individual prevention and treatment for patients suffering from alcohol dependence.

Key words: alcohol dependence, monoamine neurotransmitter, molecular mechanism, therapeutic target

Xiaohua Yang, Huafeng Zhang, Jianghua Lai. Alcohol dependence mediated by monoamine neurotransmitters in the central nervous system[J]. HEREDITAS, 2014, 36(1): 11-20.

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Alcohol dependence mediated by monoamine neurotransmitters in the central nervous system

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