ATAC-seq在复杂疾病研究中的应用进展

doi:10.16288/j.yczz.19-282

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (4): 347-353.doi: 10.16288/j.yczz.19-282

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ATAC-seq and its applications in complex disease

Min Chen¹, Zheng Zhang², Ziyuan Meng¹, Xuejun Zhang¹()

^1. Department of Dermatology and Venerology, the First Affiliated Hospital of Anhui Medical University, Heifei 230022, China
^2. Department of Dermatology and Venerology, Huashan Hospital Affiliated to Fudan University, Shanghai 201100, China

Received:2019-12-10 Revised:2020-02-16 Online:2020-04-20 Published:2020-03-06
Contact: Zhang Xuejun E-mail:ayzxj@vip.sina.com
Supported by:
Supported by the International Regional Cooperation and Exchange Programs No(81320108016)

Abstract

Abstract:

ATAC-seq is a high-throughput technology that defines and quantifies chromatin accessibility by analyzing Tn5 transposase enzymes. ATAC-seq is used to map chromatin accessibility genome-wide and to identify regions of transcription-factor binding and nucleosome position. As such, ATAC-seq is a new generation tool used in biomedical research to measure and articulate the pathogenesis of major diseases, to demonstrate the pharmacology of current drugs, and to guide the development of new drugs and the function of biomarkers. In this review, we summarize the current applications and advantages of ATAC-seq, and define its prospective contributions related to the regulatory mechanism of gene expression to identify and manage complex disease while elucidating and guiding future research references and strategies.

Key words: ATAC-seq, chromatin accessibility, Tn5 transposase, transcriptional level

Min Chen, Zheng Zhang, Ziyuan Meng, Xuejun Zhang. ATAC-seq and its applications in complex disease[J]. Hereditas(Beijing), 2020, 42(4): 347-353.

Figures/Tables 1

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