病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡

doi:10.16288/j.yczz.23-191

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (11): 986-997.doi: 10.16288/j.yczz.23-191

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Inhibiting pyroptosis: novel immune evasion strategies for pathogens

Maoyi Yang¹(), Xiaoyue Cui^2,³, Shiqi Zheng², Shiyao Ma², Zengzhang Zheng⁴(), Wanyan Deng²()

1. Key Laboratory of Molecular Biology on Infectious Disease, Ministry of Education, Chongqing Medical University，Chongqing 400010, China
2. Department of Pathogenic Biology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China
3. Department of Basic Laboratory, Suining Central Hospital, Suining 629000, China
4. Shanghai East Hospital, Tongji University, Shanghai 200120, China

Received:2023-07-18 Revised:2023-10-18 Online:2023-11-20 Published:2023-11-02
Contact: Zengzhang Zheng,Wanyan Deng E-mail:yang9910150028@163.com;dengwanyan@cqmu.edu.cn;zhengzengzhang@126.com
Supported by:
Sponsored by the Natural Science Foundation of Chongqing, China(CSTB2022NSCQ-LZX0031)

Abstract

Abstract:

Pyroptosis is a type of programmed cell death mediated by the Gasdermin family. It is triggered in response to pathogen infection or other danger signals. The activation of Gasdermins leads to pyroptosis and the release of large amounts of inflammatory cytokines. Pyroptosis plays a crucial role in combating pathogen infections, as it helps to eliminate infected cells and activate the immune system. However, pathogens have already developed sophisticated strategies to evade or inhibit pyroptosis, allowing them to persist and facilitate infection. This review provides an overview of the discovery of pyroptosis and its importance in anti-infectious immunity. We also discuss several new strategies for inhibiting pyroptosis by pathogens. A thorough learning of the occurrence and regulation of pyroptosis may reveal the pathogenesis of related infectious diseases and contribute to developing effective anti-infective therapeutic strategies.

Key words: pyroptosis, pathogen, effector protein

Maoyi Yang, Xiaoyue Cui, Shiqi Zheng, Shiyao Ma, Zengzhang Zheng, Wanyan Deng. Inhibiting pyroptosis: novel immune evasion strategies for pathogens[J]. Hereditas(Beijing), 2023, 45(11): 986-997.

Figures/Tables 2

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逃逸策略	病原体	PAMPs	作用靶点	参考文献
逃逸炎症小体识别	P. aeruginosa	PCN	NLRP3	[41]
	Y. pseudotuberculosis	YopK	NLRP3	[36]
	Y. pestis	YopM	Pyrin	[37,38]
	Sendai Virus	V Protein	NLRP3	[48]
	EVB	BILF1	NLRP3	[44]
	STm	SpvC	NLRP/NLRC4	[50]
	STm	-	NLRC4	[49]
	S. paratyphi A	Long O-antigen chains	NLRP3	[42]
	STm	SsrB	NLRC4	[43]
	STm	SopB	NLRC4	[40]
	KSHV	Orf63	NLRP1	[46]
	A. phagocytophilum	Sialostatin L2	NLRC4	[47]
	S. aureus	AdsA	NLRP3	[39]
	M. tuberculosis	Zmp1	NLRC4	[45]
重编程病原体代谢	E. piscicida	-	NLRP3	[51]
	STm	Aconitase	NLRP3	[52]
	S. aureus	PGN	Caspase-11	[53]
	Y. pestis	-	Caspase-11	[55]
	F. novicidaa	-	Caspase-11	[54,55]
抑制炎性Caspase 的活化	P. aeruginosa	ExoU	Caspase-1	[56]
	Brucella	TcpB	Caspase-1/4/11	[57]
	EPEC/EHEC	NleF	Caspase-4/11	[58,59]
	S. flexneri	OspC3	Caspase-11/4	[60,61]
	S. flexneri	IpaH9.8	GBPs	[62,63]
	C. burnetii	IcaA	Caspase-11	[64]
	EHEC	STX2	Caspase-11	[65]
抑制Gasdermin的活化	SARS-CoV-2	Nucleocapsid	Caspase1	[66]
	Enterovirus 71	3C protease	GSDMD	[67]
	S. flexneri	IpaH7.8	GSDMD/GSDMB	[68~70]
抑制GSDM-NT的成孔功能	M. tuberculosis	PtpB	GSDMD	[74,75]

Inhibiting pyroptosis: novel immune evasion strategies for pathogens

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