脉络丛及其与衰老相关疾病的关系

doi:10.16288/j.yczz.23-294

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Hereditas(Beijing) ›› 2024, Vol. 46 ›› Issue (2): 109-125.doi: 10.16288/j.yczz.23-294

• Review • Previous Articles Next Articles

Choroid plexus and its relations with age-related diseases

Yunfei Yang¹(), Yidong Shen^2,³()

1. Department of Geriatric, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
2. State Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China
3. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2023-11-30 Revised:2024-01-02 Online:2024-02-20 Published:2024-01-25
Contact: Yidong Shen E-mail:yangyunfei@sibcb.ac.cn;yidong.shen@sibcb.ac.cn
Supported by:
National Natural Science Foundation of China(32270802)

Abstract

Abstract:

The choroid plexus is composed of epithelial cells situated on the basal layer. The tight junctions between adjacent choroid plexus epithelial cells establish the blood-cerebrospinal fluid barrier. This barrier, in conjunction with the blood-brain barrier, is crucial for the homeostasis of the brain microenvironment. The choroid plexus epithelium secretes cerebrospinal fluid, growth factors, neuropeptides, and lipids into the ventricles and also serves as a gateway for immune cells to enter the brain. The pathophysiology of aging and neurodegenerative diseases remains largely enigmatic, with an increasing body of research linking the choroid plexus to the etiology of these age-related disorders. In this review, we summarize the known relationship between the choroid plexus epithelium and age-related diseases, aiming to provide new therapeutic clues for these disorders.

Key words: choroid plexus, cerebrospinal fluid, aging, neurodegenerative diseases

Yunfei Yang, Yidong Shen. Choroid plexus and its relations with age-related diseases[J]. Hereditas(Beijing), 2024, 46(2): 109-125.

Figures/Tables 2

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Choroid plexus and its relations with age-related diseases

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