Sirt1(Sirtuin type 1)是依赖于烟酰胺腺嘌呤二核苷酸(NAD⁺)的组蛋白脱乙酰酶, 为Sirtuins家族成员之一, 与细胞增殖、分化、衰老、凋亡和代谢密切相关。目前, 有关Sirt1与衰老和代谢的论文已在Science、Nature、Cell等杂志上连续刊出。其中, Sirt1通过抑制 PPARγ促进白色脂肪细胞中脂肪动员, 并且通过下调肌细胞标志基因表达来抑制成肌细胞分化。提示Sirt1不仅是一个重要的与机体“长寿”有关的因子, 而且可能在动物脂肪沉积和肌肉发育中起着关键的调控作用。

Sirt1 (Sirtuin type 1), a member of the conserved sirtuin family, is a NAD⁺ -dependent histone deacetylase. It is intimately related to cell proliferation, differentiation, apoptosis, and metabolism. Its role in senescence and metabolism has recently come to light. Sirt1 promotes fat mobilization in white adipocytes by repressing PPARγ and inhibits myoblast differentiation by down-regulating muscle gene expression. Therefore, Sirt1 is not only an important longevity factor, but also may play a key modulatory role in animal fat deposition and muscle development.