<EM>BDNF</EM>、<EM>GRIN1</EM>基因与双相情感障碍的关联研究

刘敏，凌四海，李文标，王传跃，陈大方，王刚

doi:10.1360/yc-007-0041

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2007 , Vol. 29 >Issue 1: 41 - 41―46

DOI: https://doi.org/10.1360/yc-007-0041

研究报告

BDNF、GRIN1基因与双相情感障碍的关联研究

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1. 首都医科大学附属北京安定医院科研室, 北京 100088;
2. 北京大学公共卫生学院流行病学与卫生统计学系, 北京 100083

收稿日期: 2006-03-03

修回日期: 2006-08-30

网络出版日期: 2007-01-10

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An association study between grin1, bdnf genes and bipolar disorder

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1. Beijing Anding Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100088, China
2. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China

Received date: 2006-03-03

Revised date: 2006-08-30

Online published: 2007-01-10

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摘要

为了探讨GRIN1和BDNF基因的遗传变异在双相情感障碍疾病中的相关作用, 从GRIN1、BDNF基因上各取2个SNP位点, 采用TaqMan法对100例双相情感障碍患者和100例健康人进行了单核苷酸多态性分析, 比较两组基因型频率的差异, 并使用软件SHEsis进行单体型分析。结果发现GRIN1基因上的rs2301363和hcv1840191与双相情感障碍发病的关联有统计学意义(P<0.05), 它们形成的单倍型T/G在两组人群中的分布差异亦有统计学意义(P<0.05)。而BDNF基因上的rs7103411和rs6265与双相情感障碍发病无统计学意义。实验结果表明GRIN1基因是双相情感障碍的易感基因之一。

关键词： 单核苷酸多态性; 脑衍生神经营养因子; 谷氨酸受体离子化NMDA1受体基因; N-甲基-D-天冬氨酸; 双相情感障碍

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刘敏，凌四海，李文标，王传跃，陈大方，王刚 . BDNF、GRIN1基因与双相情感障碍的关联研究[J]. 遗传, 2007 , 29(1) : 41 -41―46 . DOI: 10.1360/yc-007-0041

Abstract

in order to evaluate the role of inherited variation in GRIN1, BDNF genes in human bipolar disorder, a correlation study using 4 single nucleotide polymorphisms with GRIN1, BDNF genes(2 SNPs in every gene respectively) by means of TaqMan was performed in 100 unrelated cases subjects and 50 control subjects. Significant result was obtained that the SNPs in GRIN1 gene are related to the BP(p<0.05 ). But the SNPs in BDNF gene have no statistical significance. The result has proved again that the GRIN1 gene confers susceptibility to bipolar disorder.

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