人类线粒体DNA突变与癌症

张淑萍，宋书娟，李雅轩

doi:10.3724/SP.J.1005.2008.00263

遗传 >

2008 , Vol. 30 >Issue 3: 263 - 268

DOI: https://doi.org/10.3724/SP.J.1005.2008.00263

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人类线粒体DNA突变与癌症

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1. 首都师范大学生命科学学院, 北京 100037;
2. 北京大学医学部医学遗传学系, 北京 100083

收稿日期: 2007-09-30

修回日期: 2007-12-05

网络出版日期: 2008-03-10

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Association between mitochondrial DNA mutations and cancer in human

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1. College of Life Science, Capital Normal University, Beijing 100037, China;
2. Department of Medical Genetics, Peking University Health Science Center, Beijing 100083, China

Received date: 2007-09-30

Revised date: 2007-12-05

Online published: 2008-03-10

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摘要

细胞中的线粒体在细胞的能量代谢等功能中发挥了重要的作用。人类的肿瘤形成与线粒体DNA (mtDNA)存在着复杂的关联, 在多种癌细胞中均检测到mtDNA的突变。文章综述了癌细胞中的mtDNA突变与癌症发生的相关性, 并讨论了部分突变产生的原因及在癌症中进行mtDNA突变检测的应用前景。

关键词： 线粒体DNA; 癌细胞; 检测; 突变

本文引用格式

张淑萍，宋书娟，李雅轩 . 人类线粒体DNA突变与癌症[J]. 遗传, 2008 , 30(3) : 263 -268 . DOI: 10.3724/SP.J.1005.2008.00263

Abstract

Mitochondria are essential organelles that generate cellular energy in cells. Mutations of mitochondrial DNA (mtDNA) have been identified in various types of cancer, suggesting a complex relationship between mtDNA and cancer. This review focuses on the possible correlation between the mtDNA mutation and cancer. Additionally, possible causes for mtDNA mutations and applications for detecting mtDNA mutations in cancer are discussed.

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