棕色田鼠性别决定研究进展

闫楠，朱必才，王宇峰

doi:10.3724/SP.J.1005.2009.00587

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2009 , Vol. 31 >Issue 6: 587 - 594

DOI: https://doi.org/10.3724/SP.J.1005.2009.00587

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棕色田鼠性别决定研究进展

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徐州师范大学生命科学学院, 徐州221116

收稿日期: 2008-11-17

修回日期: 2009-03-28

网络出版日期: 2009-06-10

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Recent advances on sex determining mechanisms of Microtus mandarinus

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School of Life Science, Xuzhou Normal University, Xuzhou 221116, China

Received date: 2008-11-17

Revised date: 2009-03-28

Online published: 2009-06-10

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摘要

哺乳动物性别决定方式属于雄性异配型性别决定, 依赖于Y染色体, SRY基因是性别决定中最重要的基因。文章报道了棕色田鼠指名亚种有Y染色体, 但是Y染色体上没有SRY基因, 性别决定不依赖于SRY基因, 排除了R-spondin 1基因是性别决定基因, 同时讨论了棕色田鼠指名亚种SRY基因缺失后可能的性别决定机制。

关键词： 性别决定; SRY基因; 棕色田鼠

本文引用格式

闫楠，朱必才，王宇峰 . 棕色田鼠性别决定研究进展[J]. 遗传, 2009 , 31(6) : 587 -594 . DOI: 10.3724/SP.J.1005.2009.00587

Abstract

Most mammalian sex determination belongs to male heterogametic type of genetic sex determination. Sex de-termination of most mammals depends on the Y chromosome. SRY gene is the testis-determining factor on Y chromosome of most mammals, which is thought to be the most important gene in sex determination by far. Recent studies on Microtus mandarinus mandarinus demonstrated that the subspecies has Y chromosome, but there is no SRY gene on Y chromosome. Sex determination of Microtus mandarinus mandarinus is independent of SRY gene. R-spondin1 has also been excluded as the sex determination gene of Microtus mandarinus mandarinus. This paper reviews recent advances on sex determining mechanisms of Microtus mandarinus mandarinus. Possible sex determining mechanisms of Microtus mandarinus mandarinus in the absence of SRY gene are also discussed.

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