siRNA的体内递送

师明磊，赵志虎，王洋，陈惠鹏

doi:10.3724/SP.J.1005.2009.00683

遗传 >

2009 , Vol. 31 >Issue 7: 683 - 689

DOI: https://doi.org/10.3724/SP.J.1005.2009.00683

综述

siRNA的体内递送

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军事医学科学院生物工程研究所, 北京 100071

收稿日期: 2008-10-30

修回日期: 2009-12-19

网络出版日期: 2009-07-10

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In vivo delivery of siRNA

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Beijing Institute of Biotechnology, Beijing 100071, China

Received date: 2008-10-30

Revised date: 2009-12-19

Online published: 2009-07-10

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摘要

siRNA是一种由siRNA介导的转录后基因沉默。自利用RNAi沉默目的基因获得成功以来, 体内应用RNAi的研究受到高度重视。由于siRNA本身的不稳定性以及体内的复杂环境, siRNA递送的安全性与有效性成为目前关注的重点。文章就目前报道的siRNA体内递送方式进行了综述。

关键词： siRNA递送; siRNA; RNAi

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师明磊，赵志虎，王洋，陈惠鹏 . siRNA的体内递送[J]. 遗传, 2009 , 31(7) : 683 -689 . DOI: 10.3724/SP.J.1005.2009.00683

Abstract

RNA interference (RNAi) is a mechanism of posttranscriptional gene silencing mediated by small interfering RNA (siRNA). The ability of synthetic siRNA to silence genes in vivo has made it well suited as therapeutic drug, but the instability and polarity of siRNA and the complexity of in vivo circumstances retarded rapid development of RNAi-based therapies. In this review, a summary of the advances on in vivo siRNA delivery is presented and discussed.

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