斑马鱼血液肿瘤学的研究进展

张勇，陈芳源，邓敏

doi:10.3724/SP.J.1005.2009.00889

遗传 >

2009 , Vol. 31 >Issue 9: 889 - 895

DOI: https://doi.org/10.3724/SP.J.1005.2009.00889

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斑马鱼血液肿瘤学的研究进展

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1. 上海交通大学医学院附属仁济医院血液科上海血液学研究所白血病研究室, 上海 200127;
2. 中国科学院上海生命科学院健康科学研究所发育和疾病实验室, 上海 200025

收稿日期: 2008-08-27

修回日期: 2009-06-03

网络出版日期: 2009-09-10

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Research progress of zebrafish as a model system for hematological neoplasms

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1. Department of Hematology, RenJi Hospital and Laboratory of Leukemia, Shanghai Institute of Hematology, Shanghai Jiao Tong
University School of Medicine, Shanghai 200127, China;
2. Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China

Received date: 2008-08-27

Revised date: 2009-06-03

Online published: 2009-09-10

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摘要

斑马鱼已经成为当今人类遗传学和血液学研究的重要模式生物之一。文章介绍了斑马鱼造血系统的基本生物学特征, 并重点阐述了斑马鱼在血液肿瘤学领域的应用和研究概况, 显示了斑马鱼在血液肿瘤学的基础和临床研究方面均有着独特的应用前景, 文章对此进行了展望。

关键词： 斑马鱼; 血液肿瘤学; 动物模型

本文引用格式

张勇，陈芳源，邓敏 . 斑马鱼血液肿瘤学的研究进展[J]. 遗传, 2009 , 31(9) : 889 -895 . DOI: 10.3724/SP.J.1005.2009.00889

Abstract

Zebrafish is becoming a powerful vertebrate model for studies of human genetics and hematology. The biological characteristics of zebrafish organism, as well as its potential model for human blood developmental biology and hematologic malignancies are discussed. At last, we discussed the prospects of zebrafish in the clinical and basic research of hematological neoplasms.

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