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抑制基因组转座子活性的小RNAs在生育调节中的作用

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  • 北京大学深圳医院 男性生殖与遗传广东省重点实验室, 深圳 518036

收稿日期: 2009-05-23

  修回日期: 2009-07-17

  网络出版日期: 2010-01-15

基金资助

“985工程”资助子项目(编号:985-2-054-29), 国家自然科学基金项目(编号:30700824), 广东省医学科研基金项目(编号:A2008634)和973计划前期研究专项课题

Regulation of fertility by the small RNA pathway that defends the genome against tansposons

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  • Guangdong Province Key Laboratory of Male Reproduction and Heredity, Peking University Shenzhen Hospital, Shenzhen 518036, China

Received date: 2009-05-23

  Revised date: 2009-07-17

  Online published: 2010-01-15

摘要

小RNAs可以在转录和转录后水平沉默转座子, 最近发现的几类小RNAs(piRNAs、endo-siRNAs)均具有抑制转座子活性的作用, 其中, 果蝇piRNAs、小鼠piRNAs、小鼠endo-siRNAs及其相关蛋白主要在生殖系表达, 说明小RNAs作用途径在生殖系转座子沉默中扮演着重要角色。最新的研究揭示了小RNAs、转座子沉默、生殖生育调节之间的联系, 然而其具体作用机制尚未得到阐明。文章综述了小RNAs对基因组转座子活性的控制及其在生育调节中的作用。

关键词: 小RNAs; 生殖系; 转座抑制

本文引用格式

石敏,唐爱发,蔡志明 . 抑制基因组转座子活性的小RNAs在生育调节中的作用[J]. 遗传, 2010 , 32(1) : 11 -16 . DOI: 10.3724/SP.J.1005.2010.00011

Abstract

Small RNAs can silence transposons at transcriptional or post-transcriptional level. Newly identified small RNAs (e.g., piRNAs and endo-siRNAs) can repress the activity of transposons. Drosophila piRNAs, mouse piRNAs, mouse endo-siRNAs, and their related proteins are expressed primarily within the germline. This suggests that the small RNA pathway plays an important role in transposon silencing of the germline. Recent studies revealed the connection between small RNAs, transposon silencing, and the regulation of fertility, but the mechanism has not been clarified in detail. In this review, the advances in the control of genomic transposon activity and the regulation of fertility by the small RNA pathway were summarized and discussed.

参考文献

[1] Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermit-zakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigó R, Guyer M, Hardison RC, Haussler D, Haya-shizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karls-son EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherla-pati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leo-nard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesi-rov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Sta-benau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES. Initial sequencing and comparative analysis of the mouse genome. Nature, 2002, 420(6915): 520–562.

[2] Bourc'his D, Bestor TH. Meiotic catastrophe and retro-transposon reactivation in male germ cells lacking Dnmt3L. Nature, 2004, 431(7004): 96–99.

[3] Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, Sa-chidanandam R, Hannon GJ. Discrete small RNA- gener-ating loci as master regulators of transposon activity in Drosophila. Cell, 2007, 128(6): 1089–1103.

[4] Saito K, Nishida KM, Mori T, Kawamura Y, Miyoshi K, Nagami T, Siomi H, Siomi MC. Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev, 2006, 20(16): 2214–2222.

[5] Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. A distinct small RNA pathway silences selfish genetic ele-ments in the germline. Science, 2006, 313(5785): 320–324.

[6] Houwing S, Kamminga LM, Berezikov E, Cronembold D, Girard A, van den Elst H, Filippov DV, Blaser H, Raz E, Moens CB, Plasterk RH, Hannon GJ, Draper BW, Ketting RF. A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in zebrafish. Cell, 2007, 129(1): 69–82.

[7] Houwing S, Berezikov E, Ketting RF. Zili is required for germ cell differentiation and meiosis in zebrafish. EMBO J, 2008, 27(20): 2702–2711.

[8] Girard A, Sachidanandam R, Hannon GJ, Carmell MA. A germline-specific class of small RNAs binds mammalian Piwi

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