综述

组蛋白伴侣在发育过程中的功能

展开
  • 华中师范大学生命科学学院, 遗传调控与整合生物学湖北省重点实验室, 武汉 430079

收稿日期: 2009-04-28

  修回日期: 2009-08-01

  网络出版日期: 2010-01-15

基金资助

国家自然科学基金项目(编号:30671609)和淡水生态与生物技术国家重点实验室开放基金项目(编号:2005FB20)资助

The function of histone chaperones during development

Expand
  • Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan 430079,China

Received date: 2009-04-28

  Revised date: 2009-08-01

  Online published: 2010-01-15

摘要

组蛋白伴侣能够协助组蛋白参与染色质的解凝和组装, 从而调控基因的表达, 对动植物的配子发生、受精、胚胎发育以及生长、衰老等发育过程都具有重要作用。文章主要对目前研究较多的组蛋白伴侣 — 核质蛋白、CAF-1、HIRA、ASF1/CIA及NAP1在发育过程中的相关功能作一综述。

本文引用格式

赵占克,王玉凤 . 组蛋白伴侣在发育过程中的功能[J]. 遗传, 2010 , 32(1) : 41 -48 . DOI: 10.3724/SP.J.1005.2010.00041

Abstract

Histone chaperones may participate the decondensation and assembly of chromatins, thus regulate gene expression. They play important roles in almost all developmental processes, such as gametogenesis, fertilization, embryogenesis, growth and senescence. In this review, we used well studied examples to illustrate various functions of histone chaperones during developmental processes. Focus is given to nucleoplasmin, CAF-1, HIRA, ASF1/CIA, and NAP1.

参考文献

[1] Frehlick LJ, Eirín-López JM, Ausió J. New insights into the nucleophosin/nucleoplasmin family of nuclear chap-erones. Bioessays, 2007, 29(1): 49–59.

[2] Loyola A, Almouzni G. Histone chaperones, a supporting role in the limelight. Biochim Biophys Acta, 2004, 1677(1-3): 3–11.

[3] Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM. Roles of NPM2 in chromatin and nucleolar organization in oocytes and em-bryos. Science, 2003, 300(5619): 633–636.

[4] Philpott A, Leno GH. Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts. Cell, 1992, 69(5): 759–767.

[5] Prado A, Ramos I, Frehlick LJ, Muga A, Ausio′J. Nucleo-plasmin: a nuclear chaperone. Biochem Cell Biol, 2004, 82(4): 437–445.

[6] Wade PA, Kikyo N. Chromatin remodeling in nuclear cloning. Eur J Biochem, 2002, 269(9): 2284–2287.

[7] Lu Z, Zhang C, Zhai Z. Nucleoplasmin regulates chroma-tin condensation during apoptosis. Proc Natl Acad Sci USA, 2005, 102(8): 2778–2783.

[8] Li J, Zhang X, Sejas DP, Bagby GC, Pang Q. Hypoxia- induced nucleophosmin protects cell death through inhibition of p53. J Biol Chem, 2004, 279(40): 41275–41279.

[9] Cullen SP, Afonina IS, Donadini R, Luthi AU, Medema JP, Bird PI, Martin SJ. Nucleophosmin is cleaved and inacti-vated by the cytotoxic granule protease granzyme M dur-ing NK cell-mediated killing. J Biol Chem, 2009, 284(8): 5137–5147.

[10] Smith S, Stillman B. Purification and characterization of CAF?1, a human cell factor required for chromatin as-sembly during DNA replication in vitro. Cell, 1989, 58(1): 15–25.

[11] Kaufman PD, Kobayashi R, Stillman B. Ultraviolet radia-tion sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assem-bly factor-1. Genes Dev, 1997, 11(3): 345–357.

[12] Fischer S, Prykhozhij S, Rau MJ, Neumann CJ. Mutation of zebrafish caf-1b results in S phase arrest, defective dif-ferentiation, and p53-mediated apoptosis during organo-genesis. Cell Cycle, 2007, 6(23): 2962–2969.

[13] Gaillard PH, Martini EM, Kaufman PD, Stillman B, Moustacchi E, Almouzni G. Chromatin assembly coupled to DNA repair: a new role for chromatin assembly factor I. Cell, 1996, 86(6): 887–896.

[14] Enomoto S, Berman J. Chromatin assembly factor I con-tributes to the maintenance, but not the reestablishment, of silencing at the yeast silent mating loci. Genes Dev, 1998, 12(2): 219–232.

[15] Kaya H, Shibahara KI, Taoka KI, Iwabuchi M, Stillman B, Araki T. FASCIATA genes for chromatin assembly fac-tor-1 in Arabidopsis maintain the cellular organization of apical meristems. Cell, 2001, 104(1): 131–142.

[16] Ono T, Kaya H, Takeda S, Abe M, Ogawa Y, Kato M, Ka-kutani T, Mittelsten Scheid O, Araki T, Shibahara K. Chromatin assembly factor 1 ensures the stable mainte-nance of silent chromatin states in Arabidopsis. Genes Cells, 2006, 11(2): 153–162.

[17] Song Y, He F, Xie G, Guo X, Xu Y, Chen Y, Liang X, Stagljar I, Egli D, Ma J, Jiao R. CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory. Dev Biol, 2007, 311(1): 213–222.

[18] Klapholz B, Dietrich BH, Schaffner C, Hérédia F, Quivy JP, Almouzni G, Dostatni N. CAF-1 is required for effi-cient replication of euchromatic DNA in Drosophila larval endocycling cells. Chromosoma, 2009, 118(2): 235–248.

[19] Quivy JP, Grandi P, Almouzni G. Dimerization of the largest subunit of chromatin assembly factor 1: importance in vitro and during Xenopus early development. EMBO J, 2001, 20(8): 201

文章导航

/