Pax基因家族在果蝇发育过程中的调控作用
Regulatory functions of Pax gene family in Drosophila development
Received date: 2009-05-07
Revised date: 2009-10-29
Online published: 2010-02-15
李莉，杨杨，薛雷 . Pax基因家族在果蝇发育过程中的调控作用[J]. 遗传, 2010 , 32(2) : 115 -121 . DOI: 10.3724/SP.J.1005.2010.00115
The Pax gene family encodes a group of important transcription factors that have been evolutionary conserved from Drosophila to human. Pax genes play pivotal roles in regulating diverse signal transduction pathways and organogenesis during embryonic development through modulating cell proliferation and self-renewal, embryonic precursor cell migration, and the coordination of specific differentiation programs. Ten members of the Pax gene family, which perform crucial regulatory functions during embryonic and postembryonic development, have been identified in Drosophila. In this report, we described the protein structures, expression patterns, and main functions of Drosophila Pax genes.
Key words： Pax genes; transcription factors; Drosophila; development
[1] Bopp D, Burri M, Baumgartner S, Frigerio G, Noll M. Conservation of a large protein domain in the segmenta-tion gene paired and in functionally related genes of Drosophila. Cell, 1986, 47(6): 1033-1040.
[2] 王秀, 王蔚, 王义权. Pax基因功能及其选择性剪接的研究进展. 生命科学, 2008, 20(1): 125-130.
[3] Wehr R, Gruss P. Pax and vertebrate development. Int J Dev Biol, 1996, 40: 369-377.
[4] Bopp D, Jamet E, Baumgartner S, Burri M, Noll M. Isola-tion of two tissue-specific Drosophila Paired box genes, Pox meso and Pox neuro. EMBO J, 1989, 8(11): 2447-2457.
[5] Dambly-Chaudière C, Jamet E, Burri M, Bopp D, Basler K, Hafen E, Dumont N, Spielmann P, Ghysen A, Noll M. The paired box gene pox-neuro: a determinant of poly-innervated sense organs in Drosophila. Cell, 1992, 69(1): 159-172.
[6] Awasaki T, Kimura K. Multiple function of poxn gene in larval PNS development and in adult appendage formation of Drosophila. Dev Genes Evol, 2001, 211(1): 20-29.
[7] Layalle S, Ragone G, Giangrande A, Ghysen A, Dambly-Chaudière C. Control of bract formation in Dro-sophila: poxn, kek1, and the EGF-R pathway. Genesis, 2004, 39(4): 246-255.
[8] Boll W, Noll M. The Drosophila Pox neuro gene: control of male courtship behavior and fertility as revealed by a complete dissection of all enhancers. Development, 2002, 129(24): 5667-5681.
[9] Hall JC. The mating of a fly. Science, 1994, 264(5166): 1720-1741.
[10] Noll M. Evolution and role of Pax genes. Curr Opin Genet Dev, 1993, 3(4): 395-606.
[11] Fu W, Noll M. The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye. Genes Dev, 1997, 11(16): 2066-2078.
[12] Duan H, Zhang C, Chen J, Sink H, Frei E, Noll M. A key role of Pox meso in somatic myogenesis of Drosophila. Development, 2007, 134(22): 3985-3997.
[13] Fu W, Duan H, Frei E, Noll M. shaven and sparkling are mutations in separate enhancers of the Drosophila Pax2 homolog. Development, 1998, 125(15): 2943-3950.
[14] Flores GV, Duan H, Yan H, Nagaraj R, Fu W, Zou Y, Noll M, Banerjee U. Combinatorial signaling in the specifica-tion of unique cell fates. Cell, 2000, 103(1): 75-85.
[15] Siddall NA, Behan KJ, Crew JR, Cheung TL, Fair JA, Batterham P, Pollock JA. Mutations in lozenge and D-Pax2 invoke ectopic patterned cell death in the devel-oping Drosophila eye using distinct mechanisms. Dev Genes Evol, 2003, 213(3): 107-119.
[16] Gho M, Bellaïche Y, Schweisguth F. Revisiting the Dro-sophila microchaete lineage: a novel intrinsically asym-metric cell division generates a glial cell. Development, 1999, 126(16): 3573-3584.
[17] Kavaler J, Fu W, Duan H, Noll M, Posakony JW. An es-sential role for the Drosophila Pax2 homolog in the dif-ferentiation of adult sensory organs. Development, 1999, 126(10): 2262-2272.
[18] Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature, 1980, 287: 795-801.
[19] Baumgartner S, Noll M. Network of interactions among pair rule genes regulation paired expression during pri-mordial segmentation of Drosophila. Mech Dev, 1990, 33(1): 1-18.
[20] Small S, Levine M. The initiation of pair-rule stripes in the Drosophila blastoderm. Curr Opin Genet Dev, 1991, 1(2): 255-260.
[21] Prife M, Bejsovec A. Knowing your neighbors: Cell in-teractions determine intrasegmental patterning in Droso-phila. Trends Genet, 1992, 8(7): 243-249.
[22] St Johnston D, N&uu
/
| 〈 |
|
〉 |
www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:
