表皮干细胞研究进展
收稿日期: 2009-12-23
修回日期: 2010-02-02
网络出版日期: 2010-03-15
基金资助
国家科技支撑项目;国家自然科学基金项目
Progress in epidermal stem cells
Received date: 2009-12-23
Revised date: 2010-02-02
Online published: 2010-03-15
王丽娟，王友亮，杨晓 . 表皮干细胞研究进展[J]. 遗传, 2010 , 32(3) : 198 -204 . DOI: 10.3724/SP.J.1005.2010.00198
Mammalian skin epidermis contains different epidermal stem cell pools which contribute to the homeostasis and repair of skin epithelium. Epidermal stem cells possess two essential features common to all stem cells: self-renewal and differentiation. Disturbing the balance between self-renewal and differentiation of epidermal stem cell often causes tumors or other skin diseases. Epidermal stem cell niches provide a special microenvironment that maintains a balance of stem cell quiescence and activity. This review primarily concentrates on the following points of the epidermal stem cells: the existing evidences, the self-renewal and differentiation, the division pattern, the signal pathways regulating self-renewal and differentiation, and the microenvironment (niche) and macroenvironment maintaining the homeostasis of stem cells.
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