miR-34家族---肿瘤抑制蛋白p53高度相关microRNA
收稿日期: 2009-09-24
修回日期: 2009-11-25
网络出版日期: 2010-05-05
基金资助
国家自然科学基金项目(编号: 30872984) 和浙江省重中之重学科开放基金项目(编号: SWYX0816)资助
miR-34s—a tumor suppression protein p53 highly related microRNA
Received date: 2009-09-24
Revised date: 2009-11-25
Online published: 2010-05-05
娄文加，陈青，刘立，钱程 . miR-34家族---肿瘤抑制蛋白p53高度相关microRNA[J]. 遗传, 2010 , 32(5) : 423 -430 . DOI: 10.3724/SP.J.1005.2010.00423
Several microRNAs, most representatively the miR-34, are highly related to tumor suppression protein p53. p53 exerts its tumor suppression function known as inhibiting multiple-oncogenes, such as Bcl-2, c-myc and cell cytokines such as cyclinE2, cyclinD1 and c-Met through the regulation of miR-34. On the other hand, miR-34 enhances the activities of p53 by inhibiting silence information regulator I (SIRTI). The positive feedback regulatory network based on p53 and miR-34 families play an important role in suppression of oncogenesis and deterioration. This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment.
Key words： miR-34s; p53; feedback regulation
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