男性不育与基因缺陷
收稿日期: 2009-09-14
修回日期: 2009-11-24
网络出版日期: 2010-05-15
基金资助
安徽省自然科学基金项目(编号：050430716, 090413114)和安徽省“十五”高校学科拔尖人才基金项目资助
Male infertility and gene defects
Received date: 2009-09-14
Revised date: 2009-11-24
Online published: 2010-05-15
阮健，杜卫东 . 男性不育与基因缺陷[J]. 遗传, 2010 , 32(5) : 411 -422 . DOI: 10.3724/SP.J.1005.2010.00411
About 15% of the couples at reproductive age worldwide suffer from infertility. It is estimated that 50% of the entity result from male itself. The mechanism of male infertility is quite complicated, attributing to inherent and environment factors of the infertility patients, of which defects of fertility-related genes are of importance for its occurrence. The clinical features of male infertility vary from azoospermia to oligoasthenoteratozoospermia. This paper presents the relationship between the known defects in genes and male infertility.
Key words： male infertility; gene defects; mutation
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