KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能
收稿日期: 2009-09-27
修回日期: 2009-12-07
网络出版日期: 2010-05-15
基金资助
国家重点基础研究发展规划(973计划)项目(编号：2006CB910801), 国家高技术研究发展计划项目(863计划)(编号：2006AA02A308)和蛋白质组学国家重点实验室课题(编号：SKLP-Y200801)资助
Review for the regulatory functions of KRAB zinc finger proteins in embryonic development and tumorgenesis of higher vertebrates
Received date: 2009-09-27
Revised date: 2009-12-07
Online published: 2010-05-15
马占福，杨冬，贺福初，姜颖 . KRAB型锌指蛋白在高等脊椎动物胚胎发育和肿瘤发生、发展中的调控功能[J]. 遗传, 2010 , 32(5) : 431 -436 . DOI: 10.3724/SP.J.1005.2010.00431
KRAB-containing zinc-finger proteins (KRAB-ZFPs) first arose in the tetrapod vertebrates, and evolved quickly. Till Homo sapiens, they have become the largest family of transcription factors. Despite the molecular mechanism of transcription regulation by KRAB-ZFPs has been clarified in some degree, the higher-vertebrate-specific biological functions of the KRAB-ZFP family are still largely unknown. This review focused on the important regulatory functions of the KRAB-ZFP in embryonic development and tumorgenesis, which will benefit to the comprehensive understanding of biological roles of KRAB-ZFP in different physiological and pathological states. All of the systematic information will facilitate the further theoretical and applied studies of KRAB-ZFPs.
Key words： KRAB; embryonic development; tumor; transcription regulation
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